High-precision Cu isotopic analysis of human dietary Cu sources via multi-collector ICP-mass spectrometry.

IF 8.5 1区农林科学 Q1 CHEMISTRY, APPLIED Food Chemistry Pub Date : 2025-04-01 Epub Date: 2024-12-26 DOI:10.1016/j.foodchem.2024.142673

Kaj V Sullivan, Katharina Moser, Marta Costas-Rodríguez, Eduardo Bolea-Fernandez, Frank Vanhaecke

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Abstract

The disruption of Cu homeostasis is associated with the pathogenesis of many diseases and can result in alterations in Cu isotope fractionation. Changes in the Cu isotope ratio (⁶⁵Cu/⁶³Cu) of body fluids and tissues have been observed in liver disorders, cancers, and other diseases, displaying diagnostic/prognostic potential. However, it is not entirely clear whether certain physiological or lifestyle factors may also influence the bodily Cu isotopic composition, potentially obfuscating the signature of the pathology. To ascertain whether differences exist between food products, the Cu isotopic composition of 29 significant dietary Cu sources has been determined for the first time. The general enrichment of Cu and its heavy isotope, ⁶⁵Cu, in legumes, nuts, and seeds (major Cu sources in plant-based diets) was revealed, suggesting that individuals with plant-based diets may have a bodily Cu isotopic composition offset from that of individuals with omnivorous diets, thus requiring controlling for in study design.

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采用多收集器icp -质谱法对人类膳食铜源进行高精度铜同位素分析。

铜稳态的破坏与许多疾病的发病机制有关，并可能导致铜同位素分异的改变。在肝脏疾病、癌症和其他疾病中，已经观察到体液和组织中Cu同位素比率（65Cu/63Cu）的变化，显示出诊断/预后的潜力。然而，尚不完全清楚某些生理或生活方式因素是否也可能影响身体铜同位素组成，这可能会混淆病理特征。为了确定食品之间是否存在差异，首次测定了29种重要膳食铜源的铜同位素组成。在豆类、坚果和种子（植物性饮食中的主要铜来源）中普遍富集铜及其重同位素65Cu，这表明植物性饮食个体的身体铜同位素组成可能与杂食性饮食个体的身体铜同位素组成相抵消，因此需要在研究设计中进行控制。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.