Recent developments and applications of solid membrane in chiral separation.

IF 3.8 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS Journal of Chromatography A Pub Date : 2025-02-22 Epub Date: 2025-01-02 DOI:10.1016/j.chroma.2025.465652
Li Ge, Xinyu Li, Gege Zhu, Bing Niu, Qin Chen, Dan Zhong, Xiaodong Sun
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Abstract

Chirality is a fundamental property in nature, and chiral molecules are closely related to human health and the origin of life. Therefore, the exploration and preparation of optically active compounds of paramount importance. Membrane separation is a large-scale and continuous separation technique that has been developing quickly in recent years. It has many potential applications, particularly in chiral membrane separation technology, which is currently a hotspot for study. Depending on the types of membranes, chiral membranes can be divided into two categories: chiral solid membranes and chiral liquid membranes. Solid membranes outperform the others in terms of better mechanical performance and separation efficiency. This review presents in-depth summaries of chiral solid membranes made of different materials, and their applications in drug separation. It also providing insights into the potential for the future development of chiral solid membranes.

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固体膜在手性分离中的研究进展及应用。
手性是自然界的一种基本性质,手性分子与人类健康和生命起源密切相关。因此,探索和制备光学活性化合物具有至关重要的意义。膜分离是近年来发展迅速的一种大规模连续分离技术。它有许多潜在的应用,特别是在手性膜分离技术中,这是目前研究的热点。根据膜的类型,手性膜可分为两类:手性固体膜和手性液体膜。固体膜在机械性能和分离效率方面优于其他膜。本文综述了不同材料的手性固体膜及其在药物分离中的应用。这也为手性固体膜的未来发展提供了潜在的见解。
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来源期刊
Journal of Chromatography A
Journal of Chromatography A 化学-分析化学
CiteScore
7.90
自引率
14.60%
发文量
742
审稿时长
45 days
期刊介绍: The Journal of Chromatography A provides a forum for the publication of original research and critical reviews on all aspects of fundamental and applied separation science. The scope of the journal includes chromatography and related techniques, electromigration techniques (e.g. electrophoresis, electrochromatography), hyphenated and other multi-dimensional techniques, sample preparation, and detection methods such as mass spectrometry. Contributions consist mainly of research papers dealing with the theory of separation methods, instrumental developments and analytical and preparative applications of general interest.
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