Clinical diagnosis and treatment of G2 laryngeal neuroendocrine tumors.

IF 1.2 4区 医学 Q3 OTORHINOLARYNGOLOGY Acta Oto-Laryngologica Pub Date : 2025-01-19 DOI:10.1080/00016489.2024.2437017
Zhen Xu, Xiuyun Wu, Yanjiao Hu, Ce Wu, Xin Wang, Xiaojuan Zhang, Yong Zhang, Yichuan Huang
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Abstract

Background: Neuroendocrine tumors are rare malignancies of the head and neck, especially in the larynx. Variations in the location and morphology of laryngeal neuroendocrine tumors result in a lack of standardized clinical treatment.

Objective: This study aimed to examine the treatment and prognosis of laryngeal neuroendocrine tumors in the G2 stage.

Material and methods: Data from eight patients diagnosed with G2 stage laryngeal neuroendocrine tumors, this collection of common clinical cases was analyzed retrospectively to examine the disease's clinical characteristics, treatment, and prognosis affecting the larynx.

Results: Seven cases were supraglottic type and one was a glottic type. These cases were treated with open surgery and CO2 laser resection with support laryngoscopy, respectively. After surgery, six patients survived, one passed away due to pulmonary metastasis, and one case was lost to follow-up. OS and DSF rates at 1, 3, 5 years were 87.50%, 65.63% and 65.60%, respectively.

Conclusion and significance: The clinical manifestations of G2 stage laryngeal neuroendocrine tumors varied across different locations. Surgical resection of the lesion is the standard treatment. Selection between open neck surgery and support laryngoscope CO2 laser surgery depends on the tumor's size and location. Following radical surgery, the tumor demonstrates a favorable prognosis.

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G2喉神经内分泌肿瘤的临床诊断与治疗。
背景:神经内分泌肿瘤是一种罕见的头颈部恶性肿瘤,尤其是在喉部。喉神经内分泌肿瘤的位置和形态的变化导致缺乏标准化的临床治疗。目的:探讨喉神经内分泌肿瘤G2期的治疗及预后。材料与方法:回顾性分析8例确诊为G2期喉部神经内分泌肿瘤的临床常见病例,探讨其临床特点、治疗方法及影响喉部的预后。结果:声门上型7例,声门上型1例。这些病例分别在支持喉镜下进行开放手术和CO2激光切除术。术后6例存活,1例因肺转移死亡,1例失访。1、3、5年OS和DSF率分别为87.50%、65.63%和65.60%。结论及意义:G2期喉神经内分泌肿瘤不同部位的临床表现不同。手术切除病变是标准的治疗方法。选择开放颈部手术和支持喉镜CO2激光手术取决于肿瘤的大小和位置。根治性手术后,肿瘤预后良好。
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来源期刊
Acta Oto-Laryngologica
Acta Oto-Laryngologica 医学-耳鼻喉科学
CiteScore
2.50
自引率
0.00%
发文量
99
审稿时长
3-6 weeks
期刊介绍: Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.
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