A Hybrid Vacuum Flange RF Oscillator for Low-Cost Mass Spectrometry.

IF 3.1 2区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Journal of the American Society for Mass Spectrometry Pub Date : 2025-01-20 DOI:10.1021/jasms.4c00410
Caraleigh G Smith, Brian H Clowers, Steven J Kregel
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Abstract

In this communication we report the construction of a printed circuit board which mounts directly to the vacuum chamber of a mass spectrometer and produces the RF waveforms needed by many nonmass-selective devices such as ion guides and ion funnels. Our device is designed to replace a standard KF40 flange, can maintain vacuum chamber pressures of less than 10-6 Torr, and contains the circuitry of the open-source Wisconsin Oscillator RF power supply to generate RF waveforms of 1-4 MHz and up to 200 Vp-p. In this iteration of the Wisconsin Oscillator, we also introduce a variable resistor to control the output RF amplitude and show that its ion transmission capabilities are identical to those provided by commercial RF power supplies. With this new implementation we have greatly reduced the space and monetary requirements for driving nonmass-selective ion manipulation devices, which we expect to be advantageous to those developing low-cost and/or portable mass spectrometry systems.

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用于低成本质谱分析的混合真空法兰射频振荡器。
在本文中,我们报告了一种印刷电路板的结构,该电路板直接安装在质谱仪的真空室上,并产生许多非质量选择器件(如离子波导和离子漏斗)所需的射频波形。我们的设备旨在取代标准的KF40法兰,可以保持真空室压力小于10-6 Torr,并包含开源Wisconsin振荡器RF电源的电路,可产生1-4 MHz和高达200 Vp-p的RF波形。在威斯康星振荡器的迭代中,我们还引入了一个可变电阻来控制输出射频振幅,并表明其离子传输能力与商用射频电源提供的离子传输能力相同。有了这个新的实现,我们大大减少了驱动非质量选择性离子操作设备的空间和资金需求,我们希望这对那些开发低成本和/或便携式质谱系统的人有利。
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来源期刊
CiteScore
5.50
自引率
9.40%
发文量
257
审稿时长
1 months
期刊介绍: The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role. Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives
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