{"title":"Newly defined biomarker for the no reflow phenomenon in patients with non-ST elevation acute coronary syndrome; uric acid to creatinine ratio.","authors":"Muhsin Kalyoncuoglu, Ayca Gumusdag, Huseyin Oguz, Hasan Ogur, Semi Ozturk, Dilay Karabulut","doi":"10.1080/00015385.2025.2452101","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to investigate whether newly defined serum uric acid (SUA) to serum creatinine ratio (SUA/SCr) predicts no-reflow phenomenon (NRP) development in patients with non-ST-elevated acute coronary syndrome (NSTE-ACS).</p><p><strong>Methods: </strong>The study group was divided into two groups: those who developed NRP and those who did not. Complete blood counts, SUA, serum creatinine, C-reactive protein (CRP) and albumin were obtained at admission. The SUA/SCr, SUA to albumin ratio (UAR), C-reactive protein to albumin ratio (CAR) and systemic immune inflammation (SII) index values of all patients were calculated and their relationships with NRP were evaluated.</p><p><strong>Results: </strong>Patients with NRP had higher mean SUA/SCr ratio (7.19 ± 2.14 vs 5.30 ± 1.70, <i>p</i> < 0.001), mean UAR (1.73 ± 0.69 vs 1.38 ± 0.47, <i>p</i> < 0.001), median CAR (1.73 vs 1.54, <i>p</i> = 0.002), and median SII index (861.9 vs 730.9, <i>p</i> = 0.015) levels than in those who did not develop NRP. According to multivariant analysis models, SUA/SCr ratio, UAR, CAR and SII index were found to be independent predictors of NRP development (<i>p</i> < 0.05 for all) but only the area under the curve (AUC) for SUA/SCr ratio (AUC = 0.73, <i>p</i> < 0.001) was above the 0.70 proficiency level, performing markedly better than the other evaluated parameters. A SUA/SCr ratio ≥5.34 predicted the NRP with 75% sensitivity and 55% specificity.</p><p><strong>Conclusion: </strong>SUA/SCr ratio can be used as a reliable marker in prediction the development of NRP in NSTE-ACS patients.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"61-69"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta cardiologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00015385.2025.2452101","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The present study aimed to investigate whether newly defined serum uric acid (SUA) to serum creatinine ratio (SUA/SCr) predicts no-reflow phenomenon (NRP) development in patients with non-ST-elevated acute coronary syndrome (NSTE-ACS).
Methods: The study group was divided into two groups: those who developed NRP and those who did not. Complete blood counts, SUA, serum creatinine, C-reactive protein (CRP) and albumin were obtained at admission. The SUA/SCr, SUA to albumin ratio (UAR), C-reactive protein to albumin ratio (CAR) and systemic immune inflammation (SII) index values of all patients were calculated and their relationships with NRP were evaluated.
Results: Patients with NRP had higher mean SUA/SCr ratio (7.19 ± 2.14 vs 5.30 ± 1.70, p < 0.001), mean UAR (1.73 ± 0.69 vs 1.38 ± 0.47, p < 0.001), median CAR (1.73 vs 1.54, p = 0.002), and median SII index (861.9 vs 730.9, p = 0.015) levels than in those who did not develop NRP. According to multivariant analysis models, SUA/SCr ratio, UAR, CAR and SII index were found to be independent predictors of NRP development (p < 0.05 for all) but only the area under the curve (AUC) for SUA/SCr ratio (AUC = 0.73, p < 0.001) was above the 0.70 proficiency level, performing markedly better than the other evaluated parameters. A SUA/SCr ratio ≥5.34 predicted the NRP with 75% sensitivity and 55% specificity.
Conclusion: SUA/SCr ratio can be used as a reliable marker in prediction the development of NRP in NSTE-ACS patients.
背景：本研究旨在探讨新定义的血清尿酸（SUA）与血清肌酐比值（SUA/SCr）是否能预测非st段升高的急性冠脉综合征（NSTE-ACS）患者的无回流现象（NRP）的发展。方法：将研究组分为两组：NRP组和非NRP组。入院时进行全血细胞计数、SUA、血清肌酐、c反应蛋白（CRP）和白蛋白检测。计算所有患者的SUA/SCr、SUA/白蛋白比（UAR）、c反应蛋白/白蛋白比（CAR）和全身免疫炎症指数（SII）值，并评价其与NRP的关系。结果：NRP患者的平均SUA/SCr比（7.19±2.14 vs 5.30±1.70,p p = 0.002）和中位SII指数（861.9 vs 730.9, p = 0.015）水平高于未发生NRP的患者。通过多变量分析模型，发现SUA/SCr比值、UAR、CAR和SII指数是NRP发生的独立预测因子（p p）。结论：SUA/SCr比值可作为预测NSTE-ACS患者NRP发生的可靠指标。
期刊介绍：
Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.
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