Systemic progression of primary cutaneous anaplastic large cell lymphoma in ¹⁸F-FDG PET/CT: a case report.

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING American journal of nuclear medicine and molecular imaging Pub Date : 2024-12-15 eCollection Date: 2024-01-01 DOI:10.62347/QFCF2923

Jia Cheng, Yongkang Qiu, Lele Song, Jing Wu, Lei Kang

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Abstract

Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a type of skin T-cell lymphoma with a favorable prognosis. Some patients may experience recurrence, but systemic involvement is rare. Some studies suggest that systemic progression is associated with poor prognosis. The value of ¹⁸F-FDG PET/CT in diagnosing lymphoma has been recognized, but there is often controversy over the application value of ¹⁸F-FDG PET/CT in pcALCL. We present a rare case of pcALCL involving multiple systemic lesions, monitored and evaluated using ¹⁸F-FDG PET/CT to assist in clinical treatment decisions. Through this case, we consider that ¹⁸F-FDG PET/CT has significant value in diagnosing pcALCL. However, more clinical cases are needed to confirm whether high FDG uptake is associated with the invasiveness of pcALCL and the impact of high FDG uptake and Ki-67 expression on the progression and prognosis of pcALCL.

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18F-FDG PET/CT显示原发性皮肤间变性大细胞淋巴瘤全身性进展1例。

原发性皮肤间变性大细胞淋巴瘤（pcALCL）是一种预后良好的皮肤t细胞淋巴瘤。有些患者可能会复发，但很少累及全身。一些研究表明，全身性进展与预后不良有关。18F-FDG PET/CT在淋巴瘤诊断中的价值已得到认可，但18F-FDG PET/CT在pcALCL中的应用价值往往存在争议。我们报告一例罕见的pcALCL，涉及多个全身性病变，使用18F-FDG PET/CT进行监测和评估，以协助临床治疗决策。通过本病例，我们认为18F-FDG PET/CT对pcALCL的诊断具有重要价值。然而，高FDG摄取是否与pcALCL的侵袭性有关，以及高FDG摄取和Ki-67表达对pcALCL进展和预后的影响，还需要更多的临床病例来证实。

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来源期刊

American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

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4.00%

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期刊介绍： The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.