The Significance of Fractional Exhaled Nitric Oxide, Fractional Nasal Exhaled Nitric Oxide and Lung Function Tests in Children with Moderate-to-Severe Allergic Rhinitis.

IF 2.5 3区医学 Q1 OTORHINOLARYNGOLOGY American Journal of Rhinology & Allergy Pub Date : 2025-01-15 DOI:10.1177/19458924251313495

Wanying Li, Wanyu Jia, Xiaowen Yi, Peng Li, Chunlan Song

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Abstract

Purpose: Fractional nasal exhaled NO (FnNO), fractional exhaled NO (FeNO) and lung function tests were performed in children with moderate-to-severe persistent allergic rhinitis (AR) to investigate the significance of the above indices in the assessment and diagnosis of children with AR.

Methods: A total of 135 children with persistent AR were selected and divided into moderate-to-severe and mild groups; serum total immunoglobulin E (IgE), peripheral blood eosinophil counts (EOS), FnNO, FeNO, and lung function tests were performed.

Results: Children in the moderate-to-severe group had increased levels of FnNO and FeNO and decreased levels of forced expiratory flow at 75% of forced vital capacity as a percentage of the predicted value (FEF75%) and maximum mid-term expiratory flow as a percentage of the predicted value (MMEF%) . IgE in children with AR was positively correlated with FeNO and FnNO and negatively correlated with FEF75% . EOS was positively correlated with FnNO. FeNO was negatively correlated with FEF75% and forced expiratory flow at 50% of forced vital capacity as a percentage of the predicted value (FEF50%). FnNO was negatively correlated with FEF75%, FEF50%, and MMEF%.

Conclusion: FnNO, FeNO, and pulmonary function tests may help assess disease severity and level of disease control in children with persistent AR.

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分次呼出一氧化氮、分次鼻呼出一氧化氮和肺功能试验在中重度变应性鼻炎中的意义

目的：对中重度持续性变应性鼻炎（AR）患儿进行鼻腔呼气NO分数（FnNO）、鼻腔呼气NO分数（FeNO）和肺功能测试，探讨上述指标在评估和诊断儿童AR中的意义。方法：选取135例持续性AR患儿，分为中重度组和轻度组；血清总免疫球蛋白E （IgE）、外周血嗜酸性粒细胞计数（EOS）、FnNO、FeNO和肺功能检查。结果：中重度组患儿在用力肺活量的75%时FnNO和FeNO水平升高，用力呼气流量占预测值的百分比（FEF75%）和最大中期呼气流量占预测值的百分比（MMEF%）水平降低。AR患儿IgE与FeNO、FnNO呈正相关，与FEF75%呈负相关。EOS与FnNO呈正相关。FeNO与用力肺活量的50%时用力呼气流量占预测值的百分比（FEF50%）呈负相关。FnNO与FEF75%、FEF50%、MMEF%呈负相关。结论：FnNO、FeNO和肺功能检测有助于评估持续性AR患儿的疾病严重程度和疾病控制水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Rhinology & Allergy 医学-耳鼻喉科学

CiteScore

5.60

自引率

11.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.