Analgesic Overdose in Patients With Dental Pain. A Cross-Sectional Study in Two Dental Emergency Clinics

IF 3.3 4区 医学 Q2 PHARMACOLOGY & PHARMACY Basic & Clinical Pharmacology & Toxicology Pub Date : 2025-01-17 DOI:10.1111/bcpt.14124
Sofie Krahl Larsen, Merete Markvart, Rasmus Søndenbroe, Kim Dalhoff, Simon Storgård Jensen
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Abstract

Dental pain is common, and many patients use analgesics to alleviate the pain. Analgesics are readily accessible, and overdosing may lead to severe complications. This study explores the extent of analgesic overdosing in patients with dental pain. Data were collected from two dental emergency clinics in Copenhagen, Denmark, via questionnaires and interviews with 180 patients. Results showed that 82.8% (n = 149) had taken at least one type of analgesic, and 9% (n = 15) had exceeded the recommended maximum dosage. Of all patients with dental pain, 75.6% (n = 136) used paracetamol, 54.4% (n = 98) ibuprofen, 10% (n = 18) opioids, and 11.1% (n = 20) other types of analgesics. Most frequently, the pain was of pulpal origin (n = 119; 66.1%). Of all analgesics used, most were obtained places where guidance should be available, for example, pharmacies, dental clinics or hospitals (n = 152; 54%). The patients were aware of the recommended maximum daily dosage for paracetamol and ibuprofen in 39% (n = 70) and 41% (n = 73) of the cases, respectively. In conclusion, most patients with dental pain use analgesics to alleviate their pain. A substantial proportion of these patients overdose themselves, potentially putting them at risk of severe systemic complications. This study highlights the need for better patient education and safer pain management strategies.

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牙痛患者的镇痛药物过量。两所牙科急诊诊所的横断面研究
牙痛是常见的,许多患者使用止痛剂来减轻疼痛。镇痛剂很容易获得,过量服用可能导致严重的并发症。本研究探讨了牙痛患者镇痛药物过量的程度。通过对180名患者的问卷调查和访谈,从丹麦哥本哈根的两家牙科急诊诊所收集数据。结果显示,82.8% (n = 149)患者至少服用过一种镇痛药,9% (n = 15)患者超过推荐最大剂量。在所有牙痛患者中,75.6% (n = 136)使用扑热息痛,54.4% (n = 98)使用布洛芬,10% (n = 18)使用阿片类药物,11.1% (n = 20)使用其他类型镇痛药。最常见的是牙髓部疼痛(n = 119;66.1%)。在所有使用的止痛剂中,大多数是从应该提供指导的地方获得的,例如药房、牙科诊所或医院(n = 152;54%)。分别有39% (n = 70)和41% (n = 73)的患者知道扑热息痛和布洛芬的推荐最大日剂量。总之,大多数牙痛患者使用镇痛药来减轻疼痛。这些患者中有相当一部分人服用过量,可能使他们面临严重全身并发症的风险。这项研究强调了更好的患者教育和更安全的疼痛管理策略的必要性。
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来源期刊
CiteScore
5.60
自引率
6.50%
发文量
126
审稿时长
1 months
期刊介绍: Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
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