Association between serum copper concentration and body composition in children with spinal muscular atrophy: a cross-sectional study.

IF 1.5 4区医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2025-02-01 DOI:10.6133/apjcn.202502_34(1).0008

Qi Long, Yijie Feng, Yicheng Yu, Fei Chen, Ming Ma, Shanshan Mao

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Abstract

Background and objectives: The role of serum copper in modulating body composition in patients with spinal muscular atrophy (SMA) remains uncertain. This study aimed to illustrate the correlation between serum copper concentration and body composition in children with SMA.

Methods and study design: This study was conducted at a pediatric medical center in China from July 2019 to August 2022. The study included anthropometric measurements, serum analysis for copper, magnesium, zinc, and iron, as well as comprehensive body composition assessments. Multivariate analysis was utilized to assess the connection between serum copper concentration and body composition metrics.

Results: This cross-sectional analysis included 87 patients [median (IQR) age: 7 years (5-10), 57.5% male] diagnosed with SMA receiving comprehensive multi-disciplinary management. The results revealed a positive association between serum copper concentration and both fat mass percentage (β = 0.50, 95% confidence interval (CI): 0.07 to 0.92, p = 0.025) and fat-muscle ratio (β = 0.02, 95% CI: 0.01 to 0.03, p = 0.009). Conversely, a negative correlation was found between serum copper concentration and muscle mass percentage (β = -0.70, 95% CI: -1.11 to -0.29, p = 0.001).

Conclusions: These findings suggest a correlation between copper concentration and body composition in SMA, offering valuable insights for addressing metabolic dysregulation in these patients.

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脊髓性肌萎缩症患儿血清铜浓度与体成分的关系：一项横断面研究。

背景和目的：血清铜在调节脊髓性肌萎缩症（SMA）患者体成分中的作用仍不确定。本研究旨在阐明SMA患儿血清铜浓度与体成分的相关性。方法与研究设计：本研究于2019年7月至2022年8月在中国某儿科医学中心进行。这项研究包括人体测量、血清铜、镁、锌和铁的分析，以及全面的身体成分评估。采用多变量分析评估血清铜浓度与体成分指标之间的关系。结果：本横断面分析纳入87例确诊为SMA的患者[中位（IQR）年龄：7岁（5-10岁），57.5%为男性]，接受综合多学科治疗。结果表明，血清铜浓度与脂肪质量率（β = 0.50, 95%可信区间（CI）： 0.07 ~ 0.92, p = 0.025）和脂肌比（β = 0.02, 95% CI: 0.01 ~ 0.03, p = 0.009）呈正相关。相反，血清铜浓度与肌肉质量百分比呈负相关（β = -0.70, 95% CI: -1.11 ~ -0.29, p = 0.001）。结论：这些研究结果表明，铜浓度与SMA患者体内成分之间存在相关性，为解决这些患者的代谢失调提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia Pacific journal of clinical nutrition 医学-营养学

CiteScore

2.50

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board