{"title":"4D printing: innovative solutions and technological advances in orthopedic repair and reconstruction, personalized treatment and drug delivery.","authors":"Chenxi Shen, Aiyong Shen","doi":"10.1186/s12938-025-01334-3","DOIUrl":null,"url":null,"abstract":"<p><p>With precise control of smart materials deformation in time dimension, doctors can customize orthopedic implants. This review focuses on the advances of 4D printing technology in orthopedics, including its applications in bone repair and reconstruction, personalized treatment, and drug delivery. 4D printing enables the creation of bionic scaffolds and fixation devices for bone repair, customized implants matching patients' conditions for personalized treatment, and specific carriers for accurate drug release and delivery, which together contribute to accelerating bone healing, providing exclusive treatments, enhancing therapeutic effects and reducing side effects, thus helping improve orthopedic medicine. It offers comprehensive reference materials for relevant medical personnel.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"5"},"PeriodicalIF":2.9000,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748259/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioMedical Engineering OnLine","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1186/s12938-025-01334-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
With precise control of smart materials deformation in time dimension, doctors can customize orthopedic implants. This review focuses on the advances of 4D printing technology in orthopedics, including its applications in bone repair and reconstruction, personalized treatment, and drug delivery. 4D printing enables the creation of bionic scaffolds and fixation devices for bone repair, customized implants matching patients' conditions for personalized treatment, and specific carriers for accurate drug release and delivery, which together contribute to accelerating bone healing, providing exclusive treatments, enhancing therapeutic effects and reducing side effects, thus helping improve orthopedic medicine. It offers comprehensive reference materials for relevant medical personnel.
期刊介绍：
BioMedical Engineering OnLine is an open access, peer-reviewed journal that is dedicated to publishing research in all areas of biomedical engineering.
BioMedical Engineering OnLine is aimed at readers and authors throughout the world, with an interest in using tools of the physical and data sciences and techniques in engineering to understand and solve problems in the biological and medical sciences. Topical areas include, but are not limited to:
Bioinformatics-
Bioinstrumentation-
Biomechanics-
Biomedical Devices & Instrumentation-
Biomedical Signal Processing-
Healthcare Information Systems-
Human Dynamics-
Neural Engineering-
Rehabilitation Engineering-
Biomaterials-
Biomedical Imaging & Image Processing-
BioMEMS and On-Chip Devices-
Bio-Micro/Nano Technologies-
Biomolecular Engineering-
Biosensors-
Cardiovascular Systems Engineering-
Cellular Engineering-
Clinical Engineering-
Computational Biology-
Drug Delivery Technologies-
Modeling Methodologies-
Nanomaterials and Nanotechnology in Biomedicine-
Respiratory Systems Engineering-
Robotics in Medicine-
Systems and Synthetic Biology-
Systems Biology-
Telemedicine/Smartphone Applications in Medicine-
Therapeutic Systems, Devices and Technologies-
Tissue Engineering
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