PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury

IF 3.5 3区医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2025-02-01 DOI:10.1016/j.brainresbull.2025.111216

Na Xu , Zihuan Sun , Weikang Guan , Yiming Liu , Yun Gao , Chaoxian Yang

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Abstract

Poly (lactic-co-glycolic acid) (PLGA) is an important biomaterial for tissue defect repair, but its application in replacing missing brain tissue needs improvement. Mesenchymal stem cells (MSCs) have been used to treat various neurological diseases, but they face challenges when filling large tissue defects. The purpose of this study was to investigate the effects of PLGA combined with MSCs transplantation on brain structure and neural function in rats with traumatic brain injury (TBI), and explore its possible mechanism. The results showed that both PLGA transplantation and PLGA+MSCs transplantation could improve the brain structure and promote nerve function recovery in rats with TBI, with PLGA+MSCs transplantation being superior to PLGA transplantation. Furthermore, compared to PLGA transplantation alone, PLGA+MSCs transplantation further reduced brain injury and cell apoptosis, promoted neuron survival, and improved synaptic plasticity. Overall, the adhesion of MSCs to PLGA can enhance the therapeutic efficacy of PLGA in rats following TBI.

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PLGA支架联合MSCs移植可改善创伤性脑损伤大鼠的神经功能和脑组织结构。

聚乳酸-羟基乙酸（PLGA）是一种重要的组织缺损修复生物材料，但其在脑组织缺损替代中的应用有待提高。间充质干细胞（MSCs）已被用于治疗各种神经系统疾病，但在填充大型组织缺陷时面临挑战。本研究旨在探讨PLGA联合MSCs移植对创伤性脑损伤（TBI）大鼠脑结构和神经功能的影响，并探讨其可能机制。结果表明，PLGA移植和PLGA+MSCs移植均能改善TBI大鼠脑结构，促进神经功能恢复，且PLGA+MSCs移植优于PLGA移植。此外，与单独移植PLGA相比，PLGA+MSCs移植可进一步减轻脑损伤和细胞凋亡，促进神经元存活，改善突触可塑性。综上所述，MSCs与PLGA的粘附可以增强大鼠TBI后PLGA的治疗效果。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.