Hair Follicle Mesenchymal Stem Cells Induce Neural Regeneration and Repair after Transient Ischemic Stroke.

IF 1.5 3区医学 Q3 CLINICAL NEUROLOGY Cerebrovascular Diseases Pub Date : 2025-01-21 DOI:10.1159/000543261

Chen Yang, Lei Yu, Jia Wang, Xiaokun Wang, Yuhan Yang, Ni He, Shijing Zhang, Xu Gao, Hao Tang, Chendan Zou

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Abstract

Introduction: Considering the increasing recognition of the promising characteristic of hair follicle mesenchymal stem cells (HFMSCs) as multipotential cells with differentiation capability, in this study, we sought to investigate their hitherto unexplored therapeutic potentials in a rat model of transient ischemic stroke.

Methods: Rat transient ischemic stroke model was established to verify the effect of HFMSC transplantation. Behavioral experiment and triphenyltetrazolium chloride staining were used to estimate neurological outcome after HFMSC therapy. Pathological experiments were performed to investigate the therapeutic roles of HFMSCs.

Results: HFMSCs inhibited neural apoptosis and promoted neural proliferation. The number of neural cells around ischemic core increased after HFMSC transplantation. Besides, the transplanted HFMSCs expressed neuron-specific marker in the penumbra. Finally, HFMSCs diminished infarct area and improved neurological scores.

Conclusion: HFMSCs can improve neurological outcome via anti-apoptosis and promoting neural stem cells proliferation, highlighting their therapeutic promise for ischemic stroke treatment.

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毛囊间充质干细胞诱导短暂性脑卒中后神经再生和修复。

目的：探讨毛囊间充质干细胞（HFMSCs）在缺血性脑卒中中的作用。材料,方法：建立大鼠短暂性脑卒中模型，验证HFMSC移植的效果。采用行为学实验和TTC染色评价HFMSC治疗后的神经系统预后。通过病理实验探讨HFMSCs的治疗作用。结果：HFMSCs抑制神经细胞凋亡，促进神经细胞增殖。骨髓间充质干细胞移植后，缺血核心周围的神经细胞数量增加。此外，移植的HFMSCs在半暗区表达神经元特异性标记物。最后，HFMSCs减少了梗死面积，提高了神经学评分。结论：HFMSCs可通过抗细胞凋亡和促进神经干细胞增殖改善神经系统预后，提示其在缺血性脑卒中中的治疗潜力。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.