New Frontiers: Umbilical Cord Mesenchymal Stem Cells Uncover Developmental Roots and Biological Underpinnings of Obesity Susceptibility.

IF 9.5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Current Obesity Reports Pub Date : 2025-01-16 DOI:10.1007/s13679-024-00599-4

Lauren E Gyllenhammer, Kristen E Boyle

{"title":"New Frontiers: Umbilical Cord Mesenchymal Stem Cells Uncover Developmental Roots and Biological Underpinnings of Obesity Susceptibility.","authors":"Lauren E Gyllenhammer, Kristen E Boyle","doi":"10.1007/s13679-024-00599-4","DOIUrl":null,"url":null,"abstract":"Purpose of review: To review evidence supporting human umbilical cord mesenchymal stem cells (UC-MSC) as an innovative model system advancing obesity precision medicine.Recent findings: Obesity prevalence is increasing rapidly and exposures during fetal development can impact individual susceptibility to obesity. UC-MSCs exhibit heterogeneous phenotypes associated with maternal exposures and predictive of child cardiometabolic outcomes. This recent evidence supports UC-MSCs as a precision model serving three purposes: (1) as a mechanistic tool to interrogate biological underpinnings of obesity in human studies, (2) as a sensitive index of early life causes and determinants of obesity, and (3) as a marker and transducer of susceptibility, highlighting populations most at risk for future obesity. Data from UC-MSCs emphasize nutrient sensing and lipid partitioning as phenotypes most relevant to neonatal and early childhood adiposity and implicate a role for these cell-autonomous features of mesodermal tissues in the biological underpinnings of obesity.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"14 1","pages":"10"},"PeriodicalIF":9.5000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735562/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Obesity Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13679-024-00599-4","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: To review evidence supporting human umbilical cord mesenchymal stem cells (UC-MSC) as an innovative model system advancing obesity precision medicine.

Recent findings: Obesity prevalence is increasing rapidly and exposures during fetal development can impact individual susceptibility to obesity. UC-MSCs exhibit heterogeneous phenotypes associated with maternal exposures and predictive of child cardiometabolic outcomes. This recent evidence supports UC-MSCs as a precision model serving three purposes: (1) as a mechanistic tool to interrogate biological underpinnings of obesity in human studies, (2) as a sensitive index of early life causes and determinants of obesity, and (3) as a marker and transducer of susceptibility, highlighting populations most at risk for future obesity. Data from UC-MSCs emphasize nutrient sensing and lipid partitioning as phenotypes most relevant to neonatal and early childhood adiposity and implicate a role for these cell-autonomous features of mesodermal tissues in the biological underpinnings of obesity.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

新领域：脐带间充质干细胞揭示肥胖易感性的发育根源和生物学基础。

综述目的：综述支持人脐带间充质干细胞（UC-MSC）作为推进肥胖精准医学的创新模型系统的证据。最近的研究发现：肥胖症患病率正在迅速增加，胎儿发育期间的暴露会影响个体对肥胖症的易感性。UC-MSCs表现出与母体暴露相关的异质性表型，并可预测儿童心脏代谢结果。最近的证据支持UC-MSCs作为一种精确的模型，有三个目的：(1)作为一种机制工具，在人类研究中询问肥胖的生物学基础，(2)作为早期生活中肥胖的原因和决定因素的敏感指数，(3)作为易感性的标记和传感器，突出未来肥胖风险最高的人群。来自UC-MSCs的数据强调营养感知和脂质分配是与新生儿和幼儿肥胖最相关的表型，并暗示这些中胚层组织的细胞自主特征在肥胖的生物学基础中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current Obesity Reports Medicine-General Medicine

CiteScore

16.40

自引率

1.10%

发文量

期刊介绍： The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.