Impact of geriatric nutritional risk index on clinical outcomes in acute coronary syndrome patients: a comprehensive meta-analysis.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Coronary artery disease Pub Date : 2025-01-20 DOI:10.1097/MCA.0000000000001498

Denghong Zhang, Mingyang Tang, Nian Tang, Benjamin Samraj Prakash Earnest, Ihab Elsayed Mohamed Ali Abdou

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Abstract

Background: The Geriatric Nutritional Risk Index (GNRI), derived from serum albumin levels and body weight relative to ideal body weight, is a novel tool for assessing nutritional status. This meta-analysis explored the association between GNRI and the clinical outcomes in patients with acute coronary syndrome (ACS).

Methods: We systematically searched PubMed, Embase, and Web of Science for studies evaluating the GNRI in patients with ACS. Inclusion criteria were observational studies reporting all-cause mortality or major adverse cardiovascular events (MACEs) among ACS patients categorized by low versus normal GNRI. Data extraction and quality assessment were independently performed by two authors, utilizing a random-effects model to account for potential heterogeneity.

Results: Eleven cohort studies, encompassing 18 616 patients with ACS, were included. A low GNRI was associated with significantly increased risks of all-cause mortality (RR, 1.95; 95% CI, 1.63-2.34; P < 0.001; I² = 32%) and MACEs (RR, 1.93; 95% CI, 1.62-2.29; P < 0.001; I² = 25%). Subgroup analyses for the all-cause mortality outcome showed consistent findings across varied study designs, patient demographics, and follow-up periods (P for subgroup differences all >0.05). Sensitivity analyses conducted by sequentially excluding individual studies confirmed the stability of these results.

Conclusion: A low GNRI at the time of admission is a significant predictor of increased all-cause mortality and MACEs in patients with ACS.

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老年营养风险指数对急性冠状动脉综合征患者临床结局的影响：一项综合meta分析

背景：老年营养风险指数（GNRI）是一种评估营养状况的新工具，它来源于血清白蛋白水平和相对于理想体重的体重。本荟萃分析探讨了GNRI与急性冠脉综合征（ACS）患者临床结局之间的关系。方法：我们系统地检索PubMed， Embase和Web of Science以评估ACS患者的GNRI。纳入标准是报告低GNRI与正常GNRI分类的ACS患者的全因死亡率或主要不良心血管事件（mace）的观察性研究。数据提取和质量评估由两位作者独立完成，利用随机效应模型来解释潜在的异质性。结果：纳入了11项队列研究，包括18616例ACS患者。低GNRI与全因死亡风险显著增加相关(RR, 1.95；95% ci, 1.63-2.34；P 0.05)。通过顺序排除个别研究进行的敏感性分析证实了这些结果的稳定性。结论：入院时较低的GNRI是ACS患者全因死亡率和mace升高的重要预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.