LncRNA-DANCR: A Key Player in Colorectal Cancer Development and Progression.

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current molecular medicine Pub Date : 2025-01-16 DOI:10.2174/0115665240339328241217184041

Omid Anbiyaee, Farhoodeh Ghaedrahmati, Shirin Azizidoost, Safa Radmehr, Maryam Farzaneh, Abdolah Mousavi Salehi

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Abstract

Colorectal Cancer (CRC) is a significant global health issue, being the third most common cancer worldwide and the second most frequent cause of cancerrelated deaths. It occurs when cells in the colon or rectum grow uncontrollably, often developing from precancerous polyps. Genetic predisposition and environmental factors, such as diet and lifestyle, contribute to the disease. Recent research has focused on molecular targeted therapies and non-coding RNAs, particularly long noncoding RNAs (lncRNAs), which play a critical role in regulating CRC development and progression. DANCR interacts with microRNAs, proteins, and mRNAs, influencing gene expression and stability. DANCR functions as a promoter of tumor growth, invasion, metastasis, proliferation, migration, apoptosis, disease progression, and prognosis in various cancers. In CRC, DANCR influences both progression and clinical outcomes. This review aims to comprehensively explore the current knowledge regarding DANCR in CRC, including its molecular characteristics, expression patterns, and involvement in regulatory mechanisms, as well as its potential use as a diagnostic, prognostic, and therapeutic tool.

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LncRNA-DANCR：结直肠癌发生和发展的关键参与者。

结直肠癌（CRC）是一个重大的全球健康问题，是全球第三大常见癌症，也是导致癌症相关死亡的第二大常见原因。当结肠或直肠的细胞不受控制地生长时，通常由癌前息肉发展而来。遗传易感性和环境因素，如饮食和生活方式，都会导致这种疾病。最近的研究主要集中在分子靶向治疗和非编码rna，特别是长链非编码rna (lncRNAs)，它们在调节结直肠癌的发生和进展中起着关键作用。DANCR与microrna、蛋白质和mrna相互作用，影响基因表达和稳定性。在各种癌症中，DANCR作为肿瘤生长、侵袭、转移、增殖、迁移、凋亡、疾病进展和预后的促进因子。在结直肠癌中，DANCR影响进展和临床结果。本综述旨在全面探讨目前关于CRC中DANCR的知识，包括其分子特征、表达模式、参与调节机制，以及其作为诊断、预后和治疗工具的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular medicine 医学-医学：研究与实验

CiteScore

5.00

自引率

4.00%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.