Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy.

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2025-01-10 DOI:10.1016/j.cytogfr.2025.01.001
Songsong Wu, Zhumin Cao, Rongying Lu, Zhenwang Zhang, Gautam Sethi, Yulai You
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Abstract

Interleukin-6 (IL-6) is a pro-inflammatory cytokine playing a pivotal role during inflammation and immune responses. In the recent years, the function of IL-6 in the tumor microenvironment (TME) for affecting tumorigenesis and immunotherapy response has been investigated. The genetic mutations are mainly responsible for the development of cancer, while interactions in TME are also important, involving both cancers and non-cancerous cells. IL-6 plays a significant role in these interactions, enhancing the proliferation, survival and metastasis of tumor cells through inflammatory pathways, highlighting its carcinogenic function. Multiple immune cells including macrophages, T cells, myeloid-derived suppressor cells, dendritic cells and natural killer cells can be affected by IL-6 to develop immunosuppressive TME. IL-6 can also participate in the immune evasion through increasing levels of PD-L1, compromising the efficacy of therapeutics. Notably, IL-6 exerts a double-edge sword function and it can dually increase or decrease cancer immunotherapy, providing a challenge for targeting this cytokine in cancer therapy. Highlighting the complicated function of IL-6 in TME can lead to the development of effective therapeutics for cancer immunity.

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白细胞介素-6 (IL-6)相关的肿瘤微环境重塑和癌症免疫治疗。
白细胞介素-6 (IL-6)是一种促炎细胞因子,在炎症和免疫反应中起关键作用。近年来,人们对IL-6在肿瘤微环境(tumor microenvironment, TME)中影响肿瘤发生和免疫治疗应答的功能进行了研究。基因突变是癌症发生的主要原因,而TME中的相互作用也很重要,涉及癌症和非癌细胞。IL-6在这些相互作用中发挥重要作用,通过炎症途径增强肿瘤细胞的增殖、存活和转移,突出其致癌功能。包括巨噬细胞、T细胞、髓源性抑制细胞、树突状细胞和自然杀伤细胞在内的多种免疫细胞可受IL-6的影响而产生免疫抑制性TME。IL-6也可以通过增加PD-L1的水平参与免疫逃避,从而影响治疗的疗效。值得注意的是,IL-6具有双刃剑功能,可以双重增加或减少癌症免疫治疗,这为靶向治疗癌症提供了挑战。强调IL-6在TME中的复杂功能有助于开发有效的癌症免疫治疗方法。
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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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