Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children.

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Pub Date : 2025-01-16 DOI:10.1186/s12940-024-01151-6
Yuu-Hueih Hsu, Chih-Yin Wu, Hui-Ling Lee, Ru-Lan Hsieh, Ya-Li Huang, Horng-Sheng Shiue, Ying-Chin Lin, Mei-Chieh Chen, Yu-Mei Hsueh
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Abstract

DNA methylation is a critical step in brain development, 5-Methyl-2'-deoxycytidine (5mdC) is one of the global DNA methylation markers. Arsenic and lead exposures have been associated with neurotoxicity, which may be linked to epigenetic changes. Our research sought to investigate the correlation between 5mdC and developmental delay (DD) among preschoolers. Additionally, we assessed whether 5mdC modified the impacts of blood lead and total urinary arsenic levels on DD. We analyzed the concentrations of 5mdC, blood cadmium and lead, and total urinary arsenic in 174 children with DD and 88 healthy children. Global DNA methylation levels are expressed as the ratio 5mdC/2'-dexyguanosine (dG), called 5mdC (%). In our findings, elevated levels of blood lead and total urinary arsenic were significantly associated with DD risk among preschoolers. Furthermore, high 5mdC (%) was related with reduced risk of DD, with an odds ratio (OR) and 95% confidence interval (CI) of 0.14 (0.06 - 0.32). A notable multiplicative interaction was observed between low 5mdC (%) and elevated blood lead levels to increase OR of DD, with OR and 95% CI was 9.51 (4.18 - 21.64). The findings provide evidence of the combined effects of reduced 5mdC (%) and high blood lead concentrations, increasing the OR of DD.

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总体DNA甲基化、血铅和尿总砷水平对学龄前儿童发育迟缓的综合影响。
DNA甲基化是大脑发育的关键步骤,5-甲基-2'-脱氧胞苷(5mdC)是全球DNA甲基化标志物之一。砷和铅暴露与神经毒性有关,这可能与表观遗传变化有关。本研究旨在探讨5mdC与学龄前儿童发育迟缓(DD)之间的相关性。此外,我们评估了5mdC是否改变了血铅和尿总砷水平对DD的影响。我们分析了174名DD儿童和88名健康儿童的5mdC、血镉、铅和尿总砷浓度。全球DNA甲基化水平以5mdC/2'-脱氧鸟苷(dG)的比例表示,称为5mdC(%)。在我们的研究中,血铅和尿总砷水平的升高与学龄前儿童的DD风险显著相关。此外,高5mdC(%)与DD风险降低相关,优势比(OR)和95%置信区间(CI)为0.14(0.06 - 0.32)。低5mdC(%)和血铅水平升高之间存在显著的乘法交互作用,可增加DD的OR, OR和95% CI为9.51(4.18 - 21.64)。研究结果提供了5mdC(%)减少和血铅浓度高的联合效应的证据,增加了DD的OR。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Environmental Health
Environmental Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
10.10
自引率
1.70%
发文量
115
审稿时长
3.0 months
期刊介绍: Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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