Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review.

Q2 Pharmacology, Toxicology and Pharmaceutics F1000Research Pub Date : 2024-12-17 eCollection Date: 2023-01-01 DOI:10.12688/f1000research.141669.2

Phaniendra Alugoju, Chella Perumal Palanisamy, Naga Venkata Anusha Anthikapalli, Selvaraj Jayaraman, Anchalee Prasanskulab, Siriporn Chuchawankul, Madhu Dyavaiah, Tewin Tencomnao

{"title":"Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review.","authors":"Phaniendra Alugoju, Chella Perumal Palanisamy, Naga Venkata Anusha Anthikapalli, Selvaraj Jayaraman, Anchalee Prasanskulab, Siriporn Chuchawankul, Madhu Dyavaiah, Tewin Tencomnao","doi":"10.12688/f1000research.141669.2","DOIUrl":null,"url":null,"abstract":"Historically, plant derived natural products and their crude extracts have been used to treat a wide range of ailments across the world. Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental effects of aging and promote a healthy life span. The budding yeast Saccharomyces cerevisiae has been, and continues to be, an indispensable model organism in the field of biomedical research for discovering the molecular basis of aging S. cerevisiae has preserved nutritional signaling pathways (such as the target of rapamycin (TOR)-Sch9 and the Ras-AC-PKA (cAMP-dependent protein kinase) pathways, and shows two distinct aging paradigms chronological life span (CLS) and replicative life span (RLS). This review explores the anti-aging properties of natural products, predominantly derived from plants, and phytoextracts using S. cerevisiae as a model organism.","PeriodicalId":12260,"journal":{"name":"F1000Research","volume":"12 ","pages":"1265"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736113/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"F1000Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12688/f1000research.141669.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

Abstract

Historically, plant derived natural products and their crude extracts have been used to treat a wide range of ailments across the world. Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental effects of aging and promote a healthy life span. The budding yeast Saccharomyces cerevisiae has been, and continues to be, an indispensable model organism in the field of biomedical research for discovering the molecular basis of aging S. cerevisiae has preserved nutritional signaling pathways (such as the target of rapamycin (TOR)-Sch9 and the Ras-AC-PKA (cAMP-dependent protein kinase) pathways, and shows two distinct aging paradigms chronological life span (CLS) and replicative life span (RLS). This review explores the anti-aging properties of natural products, predominantly derived from plants, and phytoextracts using S. cerevisiae as a model organism.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

探索出芽酵母天然产物和植物提取物的抗衰老潜力综述。

从历史上看，植物衍生的天然产品及其粗提取物已被用于治疗世界各地的各种疾病。生物老年学研究旨在探索衰老的分子基础，发现新的抗衰老治疗化合物或配方，以对抗衰老的有害影响，促进健康的寿命。酿酒酵母（Saccharomyces cerevisiae）一直是并将继续是生物医学研究领域中发现衰老分子基础的不可缺少的模式生物，酿酒酵母保留了雷帕霉素靶蛋白(TOR)-Sch9和Ras-AC-PKA （camp依赖性蛋白激酶）通路等营养信号通路，并表现出两种不同的衰老范式，即时间寿命（CLS）和复制寿命（RLS）。本文综述了天然产物的抗衰老特性，主要来源于植物，以及以酿酒酵母为模式生物的植物提取物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.00

自引率

0.00%

发文量

1646

审稿时长

1 weeks

期刊介绍： F1000Research publishes articles and other research outputs reporting basic scientific, scholarly, translational and clinical research across the physical and life sciences, engineering, medicine, social sciences and humanities. F1000Research is a scholarly publication platform set up for the scientific, scholarly and medical research community; each article has at least one author who is a qualified researcher, scholar or clinician actively working in their speciality and who has made a key contribution to the article. Articles must be original (not duplications). All research is suitable irrespective of the perceived level of interest or novelty; we welcome confirmatory and negative results, as well as null studies. F1000Research publishes different type of research, including clinical trials, systematic reviews, software tools, method articles, and many others. Reviews and Opinion articles providing a balanced and comprehensive overview of the latest discoveries in a particular field, or presenting a personal perspective on recent developments, are also welcome. See the full list of article types we accept for more information.