The medium-fluorescence reticulocyte ratio is an independent predictor of G6PD deficiency neonates.

IF 1.7 4区医学 Q3 HEMATOLOGY International Journal of Hematology Pub Date : 2025-01-21 DOI:10.1007/s12185-025-03916-2

Mingliang Rao, Wenna Luo, Baojing Wu

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Abstract

Objective: G6PD deficiency is a potentially life-threatening condition in neonates presenting with hyperbilirubinemia. This study aims to identify clinical and laboratory predictors of G6PD deficiency in neonates presenting with hyperbilirubinemia.

Methods: This was a retrospective study of 227 term neonates admitted to Heyuan People's Hospital from January 2019 to October 2023. Hematological parameters and bilirubin were compared between those with G6PD deficiency and those with normal G6PD.

Results: Term neonates with G6PD deficiency had higher levels of total bilirubin, indirect bilirubin, mean corpuscular volume, mean corpuscular hemoglobin, immature reticulocyte fraction, high-fluorescence reticulocyte ratio, medium-fluorescence reticulocyte ratio, and content of reticulocytes than those with normal G6PD, but lower levels of red blood cells, hemoglobin, hematocrit, and low-fluorescence reticulocyte ratio. Medium-fluorescence ratios (OR = 1.291, P = 0.028) independently predicted G6PD deficiency in neonates. The optimal cut-off value for medium-fluorescence ratios was > 18.55%. The area under the curve for diagnosing G6PD deficiency was 0.924 (95% confidence interval: 0.886-0.962, P < 0.0001), with a sensitivity of 82.6% and specificity of 86.2%.

Conclusion: MFR emerged as a potentially valuable predictor for G6PD deficiency in neonates.

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中荧光网状细胞比率是G6PD缺乏症新生儿的独立预测因子。

目的：G6PD缺乏症是新生儿出现高胆红素血症时潜在的危及生命的疾病。本研究旨在确定以高胆红素血症为表现的新生儿G6PD缺乏症的临床和实验室预测因素。方法：对2019年1月至2023年10月在河源人民医院住院的227例足月新生儿进行回顾性研究。比较G6PD缺乏组和G6PD正常组的血液学指标和胆红素。结果：G6PD缺乏症足月新生儿总胆红素、间接胆红素、平均红细胞体积、平均红细胞血红蛋白、未成熟网织红细胞分数、高荧光网织红细胞比、中荧光网织红细胞比、网织红细胞含量均高于G6PD正常足月新生儿，红细胞、血红蛋白、红细胞压积、低荧光网织红细胞比均低于G6PD正常足月新生儿。中荧光比值（OR = 1.291, P = 0.028）独立预测新生儿G6PD缺乏症。中荧光比的最佳临界值为18.55%。诊断G6PD缺乏症的曲线下面积为0.924（95%可信区间：0.886-0.962，P）。结论：MFR是新生儿G6PD缺乏症的潜在有价值的预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hematology 医学-血液学

CiteScore

3.90

自引率

4.80%

发文量

223

审稿时长

6 months

期刊介绍： The International Journal of Hematology, the official journal of the Japanese Society of Hematology, has a long history of publishing leading research in hematology. The journal comprises articles that contribute to progress in research not only in basic hematology but also in clinical hematology, aiming to cover all aspects of this field, namely, erythrocytes, leukocytes and hematopoiesis, hemostasis, thrombosis and vascular biology, hematological malignancies, transplantation, and cell therapy. The expanded [Progress in Hematology] section integrates such relevant fields as the cell biology of stem cells and cancer cells, and clinical research in inflammation, cancer, and thrombosis. Reports on results of clinical trials are also included, thus contributing to the aim of fostering communication among researchers in the growing field of modern hematology. The journal provides the best of up-to-date information on modern hematology, presenting readers with high-impact, original work focusing on pivotal issues.