Understanding fatigue among Japanese patients with inflammatory bowel disease: insights from international comparisons and meta-analysis.

IF 3.4 Q2 GASTROENTEROLOGY & HEPATOLOGY Intestinal Research Pub Date : 2025-01-22 DOI:10.5217/ir.2024.00145

Makoto Tanaka, Momoko Takai, Sayaka Wakai, Kayoko Sakagami, Hiroaki Ito

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Abstract

Background/aims: Fatigue is a common symptom in patients with inflammatory bowel disease (IBD). The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale has demonstrated reliability and validity in assessing fatigue in patients with IBD and is used worldwide. This study aimed to examine the current state of fatigue among Japanese patients with IBD using the FACIT-F scale and to compare these findings with data from global studies through a systematic review.

Methods: Data from 488 patients with IBD treated at a specialized IBD clinic were analyzed. Patient characteristics, such as sex, age, disease duration, disease activity, FACIT-F scores, and sleep duration, were collected. A literature search identified 8 studies that met our inclusion criteria for an international comparison. A meta-analysis was performed on the Fatigue Subscale (FS) scores of FACIT-F to estimate the pooled mean.

Results: The mean FACIT-F (FS) score in this study was 39.9 ± 8.6. Four variables were significantly associated with fatigue: low Emotional Well-Being subscale scores, sleep duration < 6 hours, albumin level below the reference value, and being unmarried. The meta-analysis revealed that the pooled mean score was 40.2 (95% confidence interval, 39.5-40.9), and between-study heterogeneity was moderate (I2 = 41%).

Conclusions: The FACIT-F (FS) scores and related factors in Japanese patients with IBD demonstrated a similar trend to those in other countries. These findings can be used to identify patients in need of support and to consider interventions for modifiable factors. This study will help promote international collaborative research.

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了解日本炎症性肠病患者的疲劳：来自国际比较和荟萃分析的见解

背景/目的：疲劳是炎症性肠病（IBD）患者的常见症状。慢性疾病治疗-疲劳功能评估（FACIT-F）量表在评估IBD患者疲劳方面已经证明了可靠性和有效性，并在世界范围内使用。本研究旨在使用FACIT-F量表检查日本IBD患者的当前疲劳状态，并通过系统回顾将这些发现与全球研究的数据进行比较。方法：对在IBD专科诊所治疗的488例IBD患者的数据进行分析。收集患者特征，如性别、年龄、病程、疾病活动度、FACIT-F评分和睡眠时间。文献检索确定了8项研究符合我们的国际比较纳入标准。对FACIT-F的疲劳子量表（FS）评分进行meta分析以估计合并平均值。结果：FACIT-F （FS）评分为39.9±8.6分。四个变量与疲劳显著相关：情绪幸福感量表得分低、睡眠时间< 6小时、白蛋白水平低于参考值、未婚。meta分析显示，合并平均得分为40.2(95%可信区间为39.5-40.9)，研究间异质性中等（I2 = 41%）。结论：日本IBD患者的FACIT-F （FS）评分及其相关因素与其他国家的趋势相似。这些发现可用于识别需要支持的患者，并考虑可改变因素的干预措施。本研究将有助于促进国际合作研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intestinal Research GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.40

自引率

10.20%

发文量

审稿时长

38 weeks

期刊介绍： Intestinal Research (Intest Res) is the joint official publication of the Asian Organization for Crohn''s and Colitis (AOCC), Chinese Society of IBD (CSIBD), Japanese Society for IBD (JSIBD), Korean Association for the Study of Intestinal Diseases (KASID), Taiwan Society of IBD (TSIBD) and Colitis Crohn''s Foundation (India) (CCF, india). The aim of the Journal is to provide broad and in-depth analysis of intestinal diseases, especially inflammatory bowel disease, which shows increasing tendency and significance. As a Journal specialized in clinical and translational research in gastroenterology, it encompasses multiple aspects of diseases originated from the small and large intestines. The Journal also seeks to propagate and exchange useful innovations, both in ideas and in practice, within the research community. As a mode of scholarly communication, it encourages scientific investigation through the rigorous peer-review system and constitutes a qualified and continual platform for sharing studies of researchers and practitioners. Specifically, the Journal presents up-to-date coverage of medical researches on the physiology, epidemiology, pathophysiology, clinical presentations, and therapeutic interventions of the intestinal diseases. General topics of interest include inflammatory bowel disease, colon and small intestine cancer or polyp, endoscopy, irritable bowel syndrome and other motility disorders, infectious enterocolitis, intestinal tuberculosis, and so forth. The Journal publishes diverse types of academic materials such as editorials, clinical and basic reviews, original articles, case reports, letters to the editor, brief communications, perspective, statement or commentary, and images that are useful to clinicians and researchers.