Infection with SARS-CoV-2 during the first trimester did not adversely impact perinatal and obstetric outcomes subsequent to in vitro fertilization with frozen embryo transfer: a retrospective cohort study.

IF 3.2 3区医学 Q2 GENETICS & HEREDITY Journal of Assisted Reproduction and Genetics Pub Date : 2025-01-17 DOI:10.1007/s10815-025-03390-z

Jie Zhang, Jing Ye, Hongyuan Gao, Xiaoyan Mao, Ling Wu

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Abstract

Purpose: To investigate the impact of first-trimester COVID-19 infection on the perinatal and obstetric outcomes following in vitro fertilization-frozen embryo transfer.

Methods: This retrospective study was conducted at a university-affiliated IVF center. The infection group included women who contracted SARS-CoV-2 during the first trimester following frozen embryo transfer in China's initial pandemic wave that occurred from 7 December 2022 to 7 January 2023. The control group consisted of pregnant women from the pre-pandemic period, considering the widespread incidence of the disease among the Chinese population during such a large outbreak. The primary outcome was perinatal and obstetric parameters.

Results: A total of 346 pregnant women who tested positive for COVID-19 during the first trimester were included in the analysis, while the control group comprised 705 uninfected women (pre-COVID-19 controls). Perinatal outcomes, such as preterm birth, low birthweight, birthweight Z scores, macrosomia, small for gestational age, large for gestational age, and congenital malformations, showed no significant differences between the infected and control groups in both the unadjusted and confounder-adjusted logistic regression models. Additionally, there were no significant differences between the groups concerning obstetric complications, including gestational diabetes mellitus, hypertensive disorders of pregnancy, placenta previa, preterm premature rupture of the membrane, and mode of delivery.

Conclusion: The current study demonstrated that contracting COVID-19 during the first trimester did not adversely impact future obstetric and perinatal outcomes following in vitro fertilization-frozen embryo transfer. This data holds practical significance and offers essential insights for reproductive specialists and obstetricians advising expectant mothers.

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在妊娠早期感染SARS-CoV-2对冷冻胚胎移植体外受精后的围产期和产科结局没有不利影响：一项回顾性队列研究。

目的：探讨妊娠早期感染COVID-19对体外受精-冷冻胚胎移植后围产期和产科结局的影响。方法：本回顾性研究在一所大学附属试管婴儿中心进行。感染组包括在2022年12月7日至2023年1月7日中国最初的大流行浪潮中，在冷冻胚胎移植后的头三个月感染SARS-CoV-2的妇女。考虑到该疾病在如此大规模暴发期间在中国人口中的广泛发病率，对照组由大流行前时期的孕妇组成。主要结局是围产期和产科参数。结果：共有346名妊娠早期COVID-19检测呈阳性的孕妇被纳入分析，而对照组包括705名未感染的妇女（COVID-19前对照组）。围产期结局，如早产、低出生体重、出生体重Z评分、巨大儿、胎龄小、胎龄大和先天性畸形，在未经调整和混杂因素调整的logistic回归模型中，感染组和对照组之间没有显着差异。此外，两组在产科并发症方面无显著差异，包括妊娠糖尿病、妊娠高血压、前置胎盘、早产、胎膜早破和分娩方式。结论：目前的研究表明，在妊娠早期感染COVID-19不会对体外受精-冷冻胚胎移植后的产科和围产期结局产生不利影响。这些数据具有实际意义，并为生殖专家和产科医生建议孕妇提供必要的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.