{"title":"Delayed Inflammatory Reactions to Hyaluronic Acid Fillers: A Case Series of Novel Associations.","authors":"Rahul Nanda, Jason Covone, Joel L Cohen","doi":"10.36849/JDD.8468","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Delayed reactions to hyaluronic acid (HA) fillers have been reported following various immunologic and infectious triggers.</p><p><strong>Aim: </strong>Herein, we describe cases of delayed immunologic reactions (DIRs) following HA-soft tissue augmentation fillers precipitated by triggers not previously described in the literature. Patients: Case 1 describes a 57-year-old female with DIR to HA-filler following a motor vehicle accident in the marionette lines and nasolabial folds. Case 2 is a 54-year-old female who had a filler-related DIR following an episode of contact dermatitis shortly after laser resurfacing. Finally, in Case 3, we diagnosed a 54-year-old female with DIR to HA-filler on the hands following prolonged gardening without gloves. Conclusion: DIRs are an important filler-related complication. Practitioners need to be aware of the variable clinical presentations and a wide array of triggers. Given that these may not always be preventable, it is important for patients to understand the risk of DIRs, albeit low. J Drugs Dermatol. 2025;24(1):101-103. doi:10.36849/JDD.8468.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"24 1","pages":"101-103"},"PeriodicalIF":1.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drugs in Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.36849/JDD.8468","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Delayed reactions to hyaluronic acid (HA) fillers have been reported following various immunologic and infectious triggers.
Aim: Herein, we describe cases of delayed immunologic reactions (DIRs) following HA-soft tissue augmentation fillers precipitated by triggers not previously described in the literature. Patients: Case 1 describes a 57-year-old female with DIR to HA-filler following a motor vehicle accident in the marionette lines and nasolabial folds. Case 2 is a 54-year-old female who had a filler-related DIR following an episode of contact dermatitis shortly after laser resurfacing. Finally, in Case 3, we diagnosed a 54-year-old female with DIR to HA-filler on the hands following prolonged gardening without gloves. Conclusion: DIRs are an important filler-related complication. Practitioners need to be aware of the variable clinical presentations and a wide array of triggers. Given that these may not always be preventable, it is important for patients to understand the risk of DIRs, albeit low. J Drugs Dermatol. 2025;24(1):101-103. doi:10.36849/JDD.8468.
期刊介绍：
The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology.
We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality.
Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.
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