{"title":"Recent Trends and Perspectives on Malaria Relapse: A Mini Review.","authors":"Baburajan Radha, Praveen Kumar Bharti, Manju Rahi, Rajendra Kumar Baharia","doi":"10.4103/JVBD.JVBD_66_24","DOIUrl":null,"url":null,"abstract":"<p><p>Worldwide elimination of malaria remains a challenge yet to be accomplished, and the domain of malaria relapse equally remains obtuse. Yet sophisticated cell culture and screening techniques and animal models are being constructed and molecular regulations are discovered in this intriguing discipline. An elaborate understanding of these schemes is mandatory to conceive effective therapeutic strategies. Hence this present review details the landmark paradigms, technical advances and novel clinical interventions pertaining to malaria relapse. Keywords such as 'Malaria', 'Vivax Relapse' and 'Hypnozoites' were selected from the PubMed database, and the data were duly extracted for the present manuscript to be synthesized. In addition, special attention was given to the molecular nature and activation of hypnozoites and sexual cycles of parasites in the context of malaria relapse biology.</p>","PeriodicalId":17660,"journal":{"name":"Journal of Vector Borne Diseases","volume":" ","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Vector Borne Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/JVBD.JVBD_66_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Worldwide elimination of malaria remains a challenge yet to be accomplished, and the domain of malaria relapse equally remains obtuse. Yet sophisticated cell culture and screening techniques and animal models are being constructed and molecular regulations are discovered in this intriguing discipline. An elaborate understanding of these schemes is mandatory to conceive effective therapeutic strategies. Hence this present review details the landmark paradigms, technical advances and novel clinical interventions pertaining to malaria relapse. Keywords such as 'Malaria', 'Vivax Relapse' and 'Hypnozoites' were selected from the PubMed database, and the data were duly extracted for the present manuscript to be synthesized. In addition, special attention was given to the molecular nature and activation of hypnozoites and sexual cycles of parasites in the context of malaria relapse biology.
期刊介绍：
National Institute of Malaria Research on behalf of Indian Council of Medical Research (ICMR) publishes the Journal of Vector Borne Diseases. This Journal was earlier published as the Indian Journal of Malariology, a peer reviewed and open access biomedical journal in the field of vector borne diseases. The Journal publishes review articles, original research articles, short research communications, case reports of prime importance, letters to the editor in the field of vector borne diseases and their control.
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