{"title":"Ultrasound Erosion of Rabbit Liver Induced by Locally Injected Phase-Shift Acoustic Droplets and With Lauromacrogol.","authors":"Hui Li, Qingyue Deng, Zhiping Cai, Qin Wang, Leidan Huang, Yuejuan Gao, Xiaoxiao Dong, Litao Sun, Zheng Liu","doi":"10.1002/jum.16650","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Our previous studies have found that low-frequency, low-pressure, weakly focused ultrasound (FUS) can induce acoustic droplet vaporization (ADV) of perfluoropentane (PFP) droplets and result in localized liver and prostate tissue controllable cavitation resonance and mechanical damage. To further investigate the mechanical erosion induced by ultrasound and locally injected phase-shift acoustic droplets in rabbit liver.</p><p><strong>Methods: </strong>The liver of each rabbit was treated with perfluoromethylcyclopentane (PFMCP) alone, FUS combined with PFMCP (FUS + PFMCP), and FUS combined with PFP (FUS + PFP).</p><p><strong>Results: </strong>Two-dimensional ultrasound images showed that immediately after the completion of FUS + PFP group treatments, a high echogenicity bubble cloud could be observed, while there were no significant differences in the PFMCP and FUS + PFMCP group before and after treatment. The liver necrotic area in the FUS + PFP group was 6.2 times that of the FUS + PFMCP group (P < .05), whereas no liver necrosis was observed in the PFMCP group. At the same time, the number of vacuoles in the liver in the FUS + PFP group was approximately 70 times that of the FUS + PFMCP group (P < .001), whereas no vacuoles were observed in the PFMCP group (P < .001).</p><p><strong>Conclusions: </strong>Both FUS + PFMCP and PFMCP alone have poor mechanical erosion in liver tissue, and may even cause no damage. Only PFP droplets combined with FUS can cause significant mechanical destruction of liver tissue, leading to tissue necrosis in the droplet injection area.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ultrasound in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jum.16650","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ACOUSTICS","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: Our previous studies have found that low-frequency, low-pressure, weakly focused ultrasound (FUS) can induce acoustic droplet vaporization (ADV) of perfluoropentane (PFP) droplets and result in localized liver and prostate tissue controllable cavitation resonance and mechanical damage. To further investigate the mechanical erosion induced by ultrasound and locally injected phase-shift acoustic droplets in rabbit liver.
Methods: The liver of each rabbit was treated with perfluoromethylcyclopentane (PFMCP) alone, FUS combined with PFMCP (FUS + PFMCP), and FUS combined with PFP (FUS + PFP).
Results: Two-dimensional ultrasound images showed that immediately after the completion of FUS + PFP group treatments, a high echogenicity bubble cloud could be observed, while there were no significant differences in the PFMCP and FUS + PFMCP group before and after treatment. The liver necrotic area in the FUS + PFP group was 6.2 times that of the FUS + PFMCP group (P < .05), whereas no liver necrosis was observed in the PFMCP group. At the same time, the number of vacuoles in the liver in the FUS + PFP group was approximately 70 times that of the FUS + PFMCP group (P < .001), whereas no vacuoles were observed in the PFMCP group (P < .001).
Conclusions: Both FUS + PFMCP and PFMCP alone have poor mechanical erosion in liver tissue, and may even cause no damage. Only PFP droplets combined with FUS can cause significant mechanical destruction of liver tissue, leading to tissue necrosis in the droplet injection area.
期刊介绍：
The Journal of Ultrasound in Medicine (JUM) is dedicated to the rapid, accurate publication of original articles dealing with all aspects of medical ultrasound, particularly its direct application to patient care but also relevant basic science, advances in instrumentation, and biological effects. The journal is an official publication of the American Institute of Ultrasound in Medicine and publishes articles in a variety of categories, including Original Research papers, Review Articles, Pictorial Essays, Technical Innovations, Case Series, Letters to the Editor, and more, from an international bevy of countries in a continual effort to showcase and promote advances in the ultrasound community.
Represented through these efforts are a wide variety of disciplines of ultrasound, including, but not limited to:
-Basic Science-
Breast Ultrasound-
Contrast-Enhanced Ultrasound-
Dermatology-
Echocardiography-
Elastography-
Emergency Medicine-
Fetal Echocardiography-
Gastrointestinal Ultrasound-
General and Abdominal Ultrasound-
Genitourinary Ultrasound-
Gynecologic Ultrasound-
Head and Neck Ultrasound-
High Frequency Clinical and Preclinical Imaging-
Interventional-Intraoperative Ultrasound-
Musculoskeletal Ultrasound-
Neurosonology-
Obstetric Ultrasound-
Ophthalmologic Ultrasound-
Pediatric Ultrasound-
Point-of-Care Ultrasound-
Public Policy-
Superficial Structures-
Therapeutic Ultrasound-
Ultrasound Education-
Ultrasound in Global Health-
Urologic Ultrasound-
Vascular Ultrasound
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