Deciphering the role of cytokines in aging: Biomarker potential and effective targeting

IF 5.3 3区医学 Q2 CELL BIOLOGY Mechanisms of Ageing and Development Pub Date : 2025-01-18 DOI:10.1016/j.mad.2025.112036

Panagiotis Poulios, Stamoulis Skampouras, Christina Piperi

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Abstract

Aging is often characterized by chronic inflammation, immune system dysregulation, and cellular senescence with chronically elevated levels of pro-inflammatory cytokines. These small glycoproteins are mainly secreted by immune cells, mediating intercellular communication and immune system modulation through inflammatory signaling. Their pro- and anti-inflammatory effects make them a noteworthy research topic as well as a promising ally in combating inflammation and the aging process. Cytokines exert a synergistic role in aging and disease and may prove useful biomarkers of tissue-specific dysregulation, disease diagnosis and monitoring, presenting potential therapeutic options as anti-inflammatory and senolytic medications. In this review, we address the cellular and molecular mechanisms implicating cytokines in the aging process and related diseases, highlighting their biomarker potential. We focus on the current therapeutic strategies, including specific pharmaceutical agents, supplements, a balanced diet, and healthy habits such as exercise, stress management, and caloric restriction.

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解读细胞因子在衰老中的作用：生物标志物潜力和有效靶向。

衰老通常以慢性炎症、免疫系统失调和细胞衰老为特征，并伴有促炎细胞因子水平的长期升高。这些小糖蛋白主要由免疫细胞分泌，通过炎症信号介导细胞间通讯和免疫系统调节。它们的促炎和抗炎作用使其成为一个值得关注的研究课题，也是对抗炎症和衰老过程的有希望的盟友。细胞因子在衰老和疾病中发挥协同作用，可能被证明是组织特异性失调、疾病诊断和监测的有用生物标志物，作为抗炎和抗衰老药物提供潜在的治疗选择。在这篇综述中，我们讨论了细胞因子在衰老过程和相关疾病中的细胞和分子机制，并强调了它们的生物标志物潜力。我们关注当前的治疗策略，包括特定的药物，补充剂，均衡的饮食和健康的习惯，如运动，压力管理和热量限制。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.