Cortical beta oscillation in brain slices of hemi parkinsonian mice

IF 2.5 4区医学 Q3 NEUROSCIENCES Neuroscience Letters Pub Date : 2025-01-18 DOI:10.1016/j.neulet.2025.138128

Aidán Ortega , Antonio Laville , Montserrat Padilla-Orozco , Yohana Parrado , Dagoberto Tapia , Miguel Serrano-Reyes , Janintzitzic López-Niño , Héctor A. Vázquez-Vázquez , Elvira Galarraga , José Bargas

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Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, leading to significant motor and non-motor symptoms. Beta oscillations in cortical areas are a pathognomonic sign. Here we ask whether these oscillations can be recorded in in vitro cortical tissue despite severing the cortico-basal ganglia-thalamo-cortical loop. M1/M2 cortex of hemi parkinsonian mice (6-OHDA) was recorded with multielectrode arrays (MEAs). Spectral decomposition analysis shows a significantly augmented beta band power with respect to controls. The administration of L-DOPA diminished this exacerbated beta rhythm. This result suggests that plastic changes induced by dopamine (DA) depletion remain in isolated cortical tissue even when the complete circuit is no longer present. This finding brings the opportunity to test anti-parkinsonian drugs in vitro by quantifying cortical beta band power.

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半帕金森小鼠脑切片皮层β振荡。

帕金森病（PD）是一种神经退行性疾病，其特征是黑质致密部多巴胺能神经元的进行性丧失，导致明显的运动和非运动症状。皮层区域的β振荡是一种病征。在这里，我们询问这些振荡是否可以在体外皮层组织中记录，尽管切断了皮质-基底神经节-丘脑-皮层回路。采用多电极阵列（MEAs）对半帕金森小鼠M1/M2皮质（6-OHDA）进行记录。光谱分解分析表明，相对于控制，显著增加β波段功率。左旋多巴的使用减少了这种加剧的β节律。这一结果表明，多巴胺（DA）耗竭引起的可塑性变化在孤立的皮质组织中仍然存在，即使完整的回路不再存在。这一发现为通过量化皮质β带功率来测试抗帕金森病药物的体外测试提供了机会。

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

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