The role of 18 F-FDG PET/CT in detecting recurrence and metastasis in posttreatment nasopharyngeal carcinoma patients with elevated Epstein-Barr virus DNA.

IF 1.3 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI:10.1097/MNM.0000000000001954

Shuting Su, Ge Wang, Xiuhuan Ye, Hao Wang, Yuxuan Chen, Shaoli Song, Zhongyi Yang

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Abstract

Objective: The objective of this study is to evaluate and compare the clinical utility of 18 F-fluoro-2-deoxy-d-glucose PET and computed tomography ( 18 F-FDG PET/CT) in detecting recurrence and metastasis in patients with nasopharyngeal carcinoma (NPC) who exhibit elevated levels of Epstein-Barr virus (EBV) DNA following treatment.

Methods: A total of 103 patients with NPC were studied retrospectively. All patients were in remission following initial treatment. Elevated EBV DNA was found for the first time at review and 18 F-FDG PET/CT imaging was completed. The number of tracer lesions and the maximum standardized uptake value in the body region were recorded to evaluate the diagnostic ability of 18 F-FDG PET/CT. The final diagnosis was confirmed either through pathology or clinical follow-up lasting 6 months or longer.

Results: Out of the 103 patients, 97 patients had a total of 434 lesions that were ultimately diagnosed as recurrent or metastatic. In patient-based analyses, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 18 F-FDG PET/CT imaging were 100%, 50%, 97%, and 100%, respectively. In lesion-based analyses, the sensitivity, specificity, PPV, and NPV of 18 F-FDG PET/CT imaging were 99.3%, 30.3%, 94.9%, and 83.3%, respectively.

Conclusion: 18 F-FDG PET/CT demonstrates potential value in detecting recurrence and metastasis of NPC.

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18F-FDG PET/CT检测Epstein-Barr病毒DNA升高鼻咽癌治疗后复发和转移的作用

目的：本研究的目的是评估和比较18f -氟-2-脱氧-d-葡萄糖PET和计算机断层扫描（18F-FDG PET/CT）在检测鼻咽癌（NPC）治疗后出现eb病毒（EBV） DNA水平升高的复发和转移患者中的临床应用。方法：对103例鼻咽癌患者进行回顾性分析。所有患者在初始治疗后均缓解。复查时首次发现EBV DNA升高，并完成18F-FDG PET/CT成像。记录示踪剂病灶数量及身体部位最大标准化摄取值，评价18F-FDG PET/CT的诊断能力。最终诊断通过病理或持续6个月或更长时间的临床随访得到证实。结果：在103例患者中，97例患者总共有434个病变最终被诊断为复发或转移。在基于患者的分析中，18F-FDG PET/CT成像的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）分别为100%、50%、97%和100%。在基于病变的分析中，18F-FDG PET/CT成像的敏感性、特异性、PPV和NPV分别为99.3%、30.3%、94.9%和83.3%。结论：18F-FDG PET/CT在鼻咽癌复发转移诊断中具有潜在价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Medicine Communications 医学-核医学

CiteScore

2.20

自引率

6.70%

发文量

212

审稿时长

3-8 weeks

期刊介绍： Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.