The border effect in diamond microdosimeters and its impact on hadron therapy applications.

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL Physics in medicine and biology Pub Date : 2025-01-27 DOI:10.1088/1361-6560/adaace
Gabriele Parisi, Lucrezia Bianchi, Pierre Couture, Vladimir Palitsin, Andrea Fabbri, Giuseppe Schettino, Francesco Romano, Claudio Verona
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Abstract

Objective.The increasing interest in hadron therapy has heightened the need for accurate and reliable methods to assess radiation quality and the biological effectiveness of particles used in treatment. Microdosimetry has emerged as a key tool for this, demonstrating its potential, reliability, and suitability. In this context, solid-state microdosimeters offer technological advantages over traditional tissue-equivalent proportional counters, and recent advancements have further improved their performance and reliability. However, one critical challenge in solid-state microdosimetry is the so-called 'border effect', which can impact measurement accuracy.Approach.In this study, the border effect in diamond microdosimeters was thoroughly studied using ion beam induced charge analysis. The research, relying on experiments conducted at the Surrey Ion Beam Centre, developed an effective method to characterise and quantify the border effect. Geant4 Monte Carlo simulations were also employed to assess the impact of the border effect under typical proton therapy conditions.Main results. The border effect in diamond microdosimeter was characterised and studied as a function of detector thickness, particle atomic number and particle range. A border effect model was developed and validated to reproduce the border effect in Monte Carlo simulations. The results of its application to the microdosimetry of a proton beam at different depths in water showed potential significant variations of up to 40% iny¯Fand 20% iny¯Dvalues.Significance.The results of this work highlight the importance of accurately characterising the border effect and encouraging further research to mitigate its influence on microdosimetry measurements.

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金刚石微剂量计的边界效应及其对强子治疗应用的影响。
随着人们对强子治疗的兴趣日益浓厚,需要准确可靠的方法来评估治疗中使用的粒子的辐射质量和生物有效性。微剂量法已成为这方面的关键工具,证明了其潜力、可靠性和适用性。在这种情况下,固态微剂量计比传统的组织等效比例计数器具有技术优势,最近的进展进一步提高了其性能和可靠性。然而,固态微剂量学的一个关键挑战是所谓的“边界效应”,它会影响测量精度。本文采用离子束诱导电荷(IBIC)分析方法,对金刚石微剂量计中的边界效应进行了深入研究。这项研究依靠在萨里离子束中心进行的实验,开发了一种有效的方法来描述和量化边界效应。Geant4蒙特卡罗模拟也用于评估典型质子治疗条件下边界效应的影响,并开发和验证了一个特定的模型,以在模拟中再现这种效应。结果显示,y&# 772f值和y&# 772d值的潜在显著差异高达40%和20%,突出了准确描述边界效应的重要性,并鼓励进一步研究以减轻其对微剂量测量的影响。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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