Lower basophil count after anti-thymocyte globulin induction is associated with lower incidence of acute cellular rejection in heart transplant recipients.
Boško Skorić, Petra Mjehović, Mia Dubravčić Došen, Andrija Nekić, Dora Fabijanović, Nina Jakuš, Jure Samardžić, Ivo Planinc, Maja Čikeš, Hrvoje Gašparović, Davor Miličić
{"title":"Lower basophil count after anti-thymocyte globulin induction is associated with lower incidence of acute cellular rejection in heart transplant recipients.","authors":"Boško Skorić, Petra Mjehović, Mia Dubravčić Došen, Andrija Nekić, Dora Fabijanović, Nina Jakuš, Jure Samardžić, Ivo Planinc, Maja Čikeš, Hrvoje Gašparović, Davor Miličić","doi":"10.1016/j.trim.2025.102173","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>While lymphodepletion is considered a therapeutic effect of rabbit anti-thymocyte globulin (rATG), a concomitant decrease in basophil count (BC) has unknown clinical effect.</p><p><strong>Objective: </strong>To investigate the association between BC following rATG induction and acute cellular rejection (ACR) during the first post-HTx year.</p><p><strong>Methods: </strong>Retrospective single-center study included 183 HTx recipients receiving rATG induction between 2010 and 2021 (mean age 52 ± 13 years, 23 % female). Absolute lymphocyte count (ALC), platelet (PLT) count and BC were assessed on days 0, 7, 14, and 21 following HTx. The primary outcome was the first ACR (grade ≥1B) within the first post-HTx year.</p><p><strong>Results: </strong>Patients with ACR had significantly higher BC on day 14 (17/μL (IQR 9-43/μL) vs. 10/μL (IQR 4-19/μL), p = 0.050) and higher PLT on day 7 (143 × 10<sup>3</sup>/μL (IQR 103-168 × 10<sup>3</sup>/μL) vs. 105 × 10<sup>3</sup>/μL (IQR 68-141 × 10<sup>3</sup>/μL), p = 0.02), with higher ALC on day 14 (308/μL (IQR 171-530/μL) vs. 180/μL (IQR 93-317/μL), p = 0.016) and on day 21 (529/μL (IQR 240-610/μL) vs. 225/μL (IQR 121-328/μL), p < 0.001). In univariate analysis, ACR was associated with higher BC on day 14 (p = 0.004), higher PLT on day 7 (p = 0.02), higher ALC on days 14 (p = 0.04) and 21 (p < 0.001). Multivariable regression model showed the most significant association between higher BC on day 14 and ACR (p = 0.015).</p><p><strong>Conclusion: </strong>Lower BC two weeks after rATG induction is associated with less ACR during the first post-HTx year.</p>","PeriodicalId":23304,"journal":{"name":"Transplant immunology","volume":"89 ","pages":"102173"},"PeriodicalIF":1.6000,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplant immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.trim.2025.102173","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: While lymphodepletion is considered a therapeutic effect of rabbit anti-thymocyte globulin (rATG), a concomitant decrease in basophil count (BC) has unknown clinical effect.
Objective: To investigate the association between BC following rATG induction and acute cellular rejection (ACR) during the first post-HTx year.
Methods: Retrospective single-center study included 183 HTx recipients receiving rATG induction between 2010 and 2021 (mean age 52 ± 13 years, 23 % female). Absolute lymphocyte count (ALC), platelet (PLT) count and BC were assessed on days 0, 7, 14, and 21 following HTx. The primary outcome was the first ACR (grade ≥1B) within the first post-HTx year.
Results: Patients with ACR had significantly higher BC on day 14 (17/μL (IQR 9-43/μL) vs. 10/μL (IQR 4-19/μL), p = 0.050) and higher PLT on day 7 (143 × 103/μL (IQR 103-168 × 103/μL) vs. 105 × 103/μL (IQR 68-141 × 103/μL), p = 0.02), with higher ALC on day 14 (308/μL (IQR 171-530/μL) vs. 180/μL (IQR 93-317/μL), p = 0.016) and on day 21 (529/μL (IQR 240-610/μL) vs. 225/μL (IQR 121-328/μL), p < 0.001). In univariate analysis, ACR was associated with higher BC on day 14 (p = 0.004), higher PLT on day 7 (p = 0.02), higher ALC on days 14 (p = 0.04) and 21 (p < 0.001). Multivariable regression model showed the most significant association between higher BC on day 14 and ACR (p = 0.015).
Conclusion: Lower BC two weeks after rATG induction is associated with less ACR during the first post-HTx year.
期刊介绍:
Transplant Immunology will publish up-to-date information on all aspects of the broad field it encompasses. The journal will be directed at (basic) scientists, tissue typers, transplant physicians and surgeons, and research and data on all immunological aspects of organ-, tissue- and (haematopoietic) stem cell transplantation are of potential interest to the readers of Transplant Immunology. Original papers, Review articles and Hypotheses will be considered for publication and submitted manuscripts will be rapidly peer-reviewed and published. They will be judged on the basis of scientific merit, originality, timeliness and quality.