Hong Cheng, Shengchun Wang, Jiyuan Shao, Huiyu Gao, Ying Wang, Furong Deng, Hui Du, Jingyi Liu, Xia Du, Xin Zhang
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引用次数: 0
Abstract
Abundant epidemiological studies have conclusively demonstrated the effects of short-term ozone (O3) exposure on the incidence and mortality of cardiovascular diseases. However, the mechanism of its influence remains unverified. This study aimed to assess the impact of O3 on metabolomic-based biomarkers in acute myocardial infarction (AMI) patients. Accurate biomarkers for AMI were identified by combining serum biomarkers with metabolomics. A total of 137 volunteers were recruited, including 79 AMI patients and 58 healthy participants, from March to April 2023 in Taiyuan, China. Linear regression models were applied to analyze the associations of serum biomarkers and metabolites with O3. Mediation analyses were also conducted to assess the impact of metabolites, acting as mediators, on the associations between O3 and biomarkers. We found that O3 at lag2 captured the most remarkable effects. Metabolomic analysis revealed a substantial association between O3 (lag2) and 43 metabolites. Pathway analysis revealed that these metabolites primarily participate in the tricarboxylic acid cycle, arginine biosynthesis, and histidine metabolism. These findings suggest that O3 is an important factor in examining the metabolic mechanisms of cardiovascular disease, highlighting the importance of mitigating O3 to further protect AMI patients.
期刊介绍：
Environment & Health a peer-reviewed open access journal is committed to exploring the relationship between the environment and human health.As a premier journal for multidisciplinary research Environment & Health reports the health consequences for individuals and communities of changing and hazardous environmental factors. In supporting the UN Sustainable Development Goals the journal aims to help formulate policies to create a healthier world.Topics of interest include but are not limited to:Air water and soil pollutionExposomicsEnvironmental epidemiologyInnovative analytical methodology and instrumentation (multi-omics non-target analysis effect-directed analysis high-throughput screening etc.)Environmental toxicology (endocrine disrupting effect neurotoxicity alternative toxicology computational toxicology epigenetic toxicology etc.)Environmental microbiology pathogen and environmental transmission mechanisms of diseasesEnvironmental modeling bioinformatics and artificial intelligenceEmerging contaminants (including plastics engineered nanomaterials etc.)Climate change and related health effectHealth impacts of energy evolution and carbon neutralizationFood and drinking water safetyOccupational exposure and medicineInnovations in environmental technologies for better healthPolicies and international relations concerned with environmental health
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