The Significant Role of Atopic Skin Diathesis in Prurigo Nodularis.

IF 1 Q3 MEDICINE, GENERAL & INTERNAL Medical Bulletin of Sisli Etfal Hospital Pub Date : 2024-12-24 eCollection Date: 2024-01-01 DOI:10.14744/SEMB.2024.46144
Yasemin Erdem, Ozgke Impram Ntousounous, Esen Ozkaya
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Abstract

Objectives: Atopic skin plays a significant etiological role in the development of prurigo nodularis (PN). In addition to atopic dermatitis (AD), atopic skin diathesis without eczema can also contribute to the development of PN due to its association with itching. This study aims to evaluate PN in terms of AD/atopic skin diathesis, associated comorbidities, and clinical findings.

Methods: Patients diagnosed with PN based on clinical and histopathological findings between 2014 and 2024 were included in the study. Associated diseases that could contribute to the etiology of pruritus were recorded as comorbidities. The diagnosis of AD was evaluated using the Hanifin-Rajka's diagnostic criteria and atopic skin diathesis using the Erlangen Atopy Score. Patients were classified as atopic and non-atopic groups, and these groups were compared in terms of demographic and clinical findings.

Results: The study included a total of 47 patients, of whom 15 (31.9%) were male and 32 (68.1%) were female. At least one comorbidity was identified in 89.4% (n=42) of the patients, and multiple comorbidities were found in 34% (n=16). Atopic dermatitis and/or atopic skin diathesis were present in 55.3% (n=26) of the patients. Among these, 53.8% (n=14) were diagnosed with AD, while 46.2% (n=12) had only an atopic skin diathesis. Compared to the non-atopic group, the atopic group had a lower median age (p=0.001) and higher serum total IgE levels (p=0.031).

Conclusion: In addition to AD, atopic skin diathesis without eczema also appears to play an important role in the etiology of PN. The lower age and higher IgE levels in patients are factors associated with atopic predisposition.

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特应性皮肤素质在结节性痒疹中的重要作用。
目的:特应性皮肤在结节性痒疹(PN)的发展中起着重要的病因学作用。除了特应性皮炎(AD)外,没有湿疹的特应性皮肤素质也可以促进PN的发展,因为它与瘙痒有关。本研究旨在评估PN在AD/特应性皮肤素质、相关合并症和临床表现方面的影响。方法:选取2014 - 2024年间经临床及组织病理学诊断为PN的患者。可能导致瘙痒病因的相关疾病被记录为合并症。采用Hanifin-Rajka诊断标准和Erlangen特应性评分对AD的诊断进行评估。将患者分为特应性组和非特应性组,并对这些组进行人口学和临床结果的比较。结果:共纳入47例患者,其中男性15例(31.9%),女性32例(68.1%)。89.4% (n=42)的患者至少存在一种合并症,34% (n=16)的患者存在多种合并症。55.3% (n=26)的患者存在特应性皮炎和/或特应性皮肤素质。其中,53.8% (n=14)被诊断为AD, 46.2% (n=12)仅为特应性皮肤素质。与非特应性组相比,特应性组的中位年龄较低(p=0.001),血清总IgE水平较高(p=0.031)。结论:除AD外,无湿疹的特应性皮肤素质在PN的病因中也起重要作用。患者较低的年龄和较高的IgE水平是与特应性易感性相关的因素。
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来源期刊
Medical Bulletin of Sisli Etfal Hospital
Medical Bulletin of Sisli Etfal Hospital MEDICINE, GENERAL & INTERNAL-
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41
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