The functional regulation between extracellular vesicles and the DNA damage responses

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation Research-Reviews in Mutation Research Pub Date : 2025-01-01 DOI:10.1016/j.mrrev.2025.108532

Jinyi Han , Kexin Xu , Ting Xu , Qin Song , Ting Duan , Jun Yang

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Abstract

The DNA damage response (DDR) is a crucial regulatory mechanism for the survival of organisms, and irregularity of DDR may contribute to the development of various diseases, including tumors, making it is a prominent topic in therapeutic research. Extracellular vesicles (EVs), as important mediators of intercellular communication, have been extensively studied in recent years. Notably, an increasing number of studies have revealed a strong connection between DDR and EVs. On one hand, DNA damage affects the release of EVs and their compositional content; on the other hand, EVs can dictate cell survival or death by modulating DDR in both the parental and the recipient cells. This review outlines current progress in the inter-regulatory relationship between EVs and DDR, with special emphasis on the effects of EVs derived from various sources on DDR in recipient cells. In addition, the potential applications of EVs in research and tumor therapy are discussed.

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细胞外囊泡与DNA损伤反应的功能调控。

DNA损伤反应（DNA damage response， DDR）是生物体生存的重要调控机制，DDR的异常可能与包括肿瘤在内的多种疾病的发生发展有关，是目前治疗研究的热点。细胞外囊泡（Extracellular vesicles, EVs）作为细胞间通讯的重要介质，近年来得到了广泛的研究。值得注意的是，越来越多的研究揭示了DDR与电动汽车之间的密切联系。DNA损伤一方面影响ev的释放及其成分含量；另一方面，ev可以通过调节亲本细胞和受体细胞中的DDR来决定细胞的存活或死亡。本文概述了ev与DDR之间调控关系的最新进展，特别强调了各种来源的ev对受体细胞中DDR的影响。此外，还讨论了ev在研究和肿瘤治疗中的潜在应用。

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.