Insulin Delivery Pumps for Human Spaceflight: Steps Toward an Accessible Space Future.

IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Wilderness & Environmental Medicine Pub Date : 2025-01-17 DOI:10.1177/10806032241304439
Kyle J Horn, Jeffrey A Hoffman
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Abstract

Commercially available insulin pumps for treatment of diabetes mellitus are currently not qualified to operate in the space environment. This work rigorously tested the fluid delivery performance of a Tandem t:slim X2 insulin pump in both micro- and hypergravity during a parabolic microgravity research flight. The parabolic research flight environment serves as an analogue to the types of transient gravitational loadings experienced during human-led missions, which provides a foundation to expand testing to suborbital and orbital flights in addition to other extreme environmental tests for wilderness dependency. The results of the flight data showed no significant difference between fluid delivery performance at 0, 1, and 2g acceleration regimes, nor at the transitions between gravity environments. Recommendations are made for further experimentation and qualification tests before use in future spaceflight missions.

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用于人类太空飞行的胰岛素输送泵:迈向可到达的太空未来的步骤。
用于治疗糖尿病的市售胰岛素泵目前还不适合在太空环境中运行。在抛物线微重力研究飞行中,严格测试了Tandem t:slim X2胰岛素泵在微重力和超重力下的流体输送性能。抛物线研究飞行环境与人类主导的任务中所经历的瞬态重力载荷类型类似,为将测试扩展到亚轨道和轨道飞行以及其他野外依赖的极端环境测试提供了基础。飞行数据的结果显示,在0、1和2g加速状态下,流体输送性能没有显著差异,在重力环境之间的转换也没有显著差异。建议在将来的航天飞行任务中使用之前进行进一步的实验和合格测试。
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来源期刊
Wilderness & Environmental Medicine
Wilderness & Environmental Medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
2.10
自引率
7.10%
发文量
96
审稿时长
>12 weeks
期刊介绍: Wilderness & Environmental Medicine, the official journal of the Wilderness Medical Society, is the leading journal for physicians practicing medicine in austere environments. This quarterly journal features articles on all aspects of wilderness medicine, including high altitude and climbing, cold- and heat-related phenomena, natural environmental disasters, immersion and near-drowning, diving, and barotrauma, hazardous plants/animals/insects/marine animals, animal attacks, search and rescue, ethical and legal issues, aeromedial transport, survival physiology, medicine in remote environments, travel medicine, operational medicine, and wilderness trauma management. It presents original research and clinical reports from scientists and practitioners around the globe. WEM invites submissions from authors who want to take advantage of our established publication''s unique scope, wide readership, and international recognition in the field of wilderness medicine. Its readership is a diverse group of medical and outdoor professionals who choose WEM as their primary wilderness medical resource.
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