Risk of Malignant Transformation of Oral Lichen Planus and Oral Lichenoid Lesions: A Single Centre, 10-Year Review.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-01-16 DOI:10.1002/hed.28070

Kelsey V Won, Karl K Cuddy, Deepika Chugh, Marco Magalhaes

{"title":"Risk of Malignant Transformation of Oral Lichen Planus and Oral Lichenoid Lesions: A Single Centre, 10-Year Review.","authors":"Kelsey V Won, Karl K Cuddy, Deepika Chugh, Marco Magalhaes","doi":"10.1002/hed.28070","DOIUrl":null,"url":null,"abstract":"Background: Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are common chronic inflammatory diseases associated with malignant transformation. Risk factors associated with malignant transformation of OLP and OLL are not well defined.Methods: A retrospective chart review assessed risk factors for progression of OLP and OLL to oral epithelial dysplasia (OED) or oral squamous cell carcinoma (OSCC) at a tertiary care centre in Toronto, Canada.Results: Five-hundred-fifty-five patients identified with biopsy proven OLP or OLL met the inclusion criteria. In total, 3.2% (n = 18) progressed to OED (1.8%, n = 10) or OSCC (1.4%, n = 8). Risk factors associated with transformation included the plaque-like subtype (OR = 40.33, p < 0.001) and lesions located on the tongue (OR = 6.81, p = 0.008).Conclusions: Clinical examination to identify lesion subtype and location provides useful indicators for risk of progression in patients with OLL and OLP.","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.28070","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Oral lichen planus (OLP) and oral lichenoid lesions (OLL) are common chronic inflammatory diseases associated with malignant transformation. Risk factors associated with malignant transformation of OLP and OLL are not well defined.

Methods: A retrospective chart review assessed risk factors for progression of OLP and OLL to oral epithelial dysplasia (OED) or oral squamous cell carcinoma (OSCC) at a tertiary care centre in Toronto, Canada.

Results: Five-hundred-fifty-five patients identified with biopsy proven OLP or OLL met the inclusion criteria. In total, 3.2% (n = 18) progressed to OED (1.8%, n = 10) or OSCC (1.4%, n = 8). Risk factors associated with transformation included the plaque-like subtype (OR = 40.33, p < 0.001) and lesions located on the tongue (OR = 6.81, p = 0.008).

Conclusions: Clinical examination to identify lesion subtype and location provides useful indicators for risk of progression in patients with OLL and OLP.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

口腔扁平苔藓和口腔苔藓样病变恶性转化的风险：单一中心，10年回顾。

背景：口腔扁平苔藓（OLP）和口腔苔藓样病变（OLL）是常见的与恶性转化相关的慢性炎症性疾病。与OLP和OLL恶性转化相关的危险因素尚未明确。方法：在加拿大多伦多的一家三级保健中心，回顾性图表评估了OLP和OLL进展为口腔上皮发育不良（OED）或口腔鳞状细胞癌（OSCC）的危险因素。结果：555例活检证实为OLP或OLL的患者符合纳入标准。总的来说,3.2% (n = 18)发展到牛津英语词典》(1.8%,n = 10)或OSCC (1.4%, n = 8)。与转化相关的危险因素包括斑块样亚型（OR = 40.33, p）。结论：临床检查确定病变亚型和位置为OLL和OLP患者的进展风险提供了有用的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.

期刊最新文献

Postoperative Management Following Endoscopic Skull Base Reconstruction: A Multidisciplinary Cross-Sectional Survey. Upper Aerodigestive Tract Liposarcoma: Four Cases of a Rare Entity and a Review of the Literature. Front Cover Issue Information Factors Increasing the Likelihood of Postoperative Hematomas Following Thyroid Surgery.