Research progress of mosquito-borne virus mRNA vaccines.

IF 4.6 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Molecular Therapy-Methods & Clinical Development Pub Date : 2024-12-12 eCollection Date: 2025-03-13 DOI:10.1016/j.omtm.2024.101398

Ningze Sun, Zhiwei Su, Xiaoyan Zheng

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Abstract

In recent years, mRNA vaccines have emerged as a leading technology for preventing infectious diseases due to their rapid development and high immunogenicity. These vaccines encode viral antigens, which are translated into antigenic proteins within host cells, inducing both humoral and cellular immune responses. This review systematically examines the progress in mRNA vaccine research for major mosquito-borne viruses, including dengue virus, Zika virus, Japanese encephalitis virus, Chikungunya virus, yellow fever virus, Rift Valley fever virus, and Venezuelan equine encephalitis virus. Enhancements in mRNA vaccine design, such as improvements to the 5' cap structure, 5'UTR, open reading frame, 3'UTR, and polyadenylation tail, have significantly increased mRNA stability and translation efficiency. Additionally, the use of lipid nanoparticles and polymer nanoparticles has greatly improved the delivery efficiency of mRNA vaccines. Currently, mRNA vaccines against mosquito-borne viruses are under development and clinical trials, showing promising protective effects. Future research should continue to optimize vaccine design and delivery systems to achieve broad-spectrum and long-lasting protection against various mosquito-borne virus infections.

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蚊媒病毒mRNA疫苗研究进展。

近年来，mRNA疫苗因其快速发展和高免疫原性而成为预防传染病的主要技术。这些疫苗编码病毒抗原，这些抗原在宿主细胞内被翻译成抗原蛋白，诱导体液和细胞免疫反应。本文系统综述了登革热病毒、寨卡病毒、日本脑炎病毒、基孔肯雅病毒、黄热病病毒、裂谷热病毒和委内瑞拉马脑炎病毒等主要蚊媒病毒mRNA疫苗的研究进展。mRNA疫苗设计的改进，如对5‘帽结构、5’ utr、开放阅读框、3'UTR和聚腺苷化尾部的改进，显著提高了mRNA的稳定性和翻译效率。此外，脂质纳米颗粒和聚合物纳米颗粒的使用大大提高了mRNA疫苗的递送效率。目前，针对蚊媒病毒的mRNA疫苗正在开发和临床试验中，显示出有希望的保护作用。未来的研究应继续优化疫苗设计和递送系统，以实现对各种蚊媒病毒感染的广谱和持久保护。

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来源期刊

Molecular Therapy-Methods & Clinical Development Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.90

自引率

4.30%

发文量

163

审稿时长

12 weeks

期刊介绍： The aim of Molecular Therapy—Methods & Clinical Development is to build upon the success of Molecular Therapy in publishing important peer-reviewed methods and procedures, as well as translational advances in the broad array of fields under the molecular therapy umbrella. Topics of particular interest within the journal''s scope include: Gene vector engineering and production, Methods for targeted genome editing and engineering, Methods and technology development for cell reprogramming and directed differentiation of pluripotent cells, Methods for gene and cell vector delivery, Development of biomaterials and nanoparticles for applications in gene and cell therapy and regenerative medicine, Analysis of gene and cell vector biodistribution and tracking, Pharmacology/toxicology studies of new and next-generation vectors, Methods for cell isolation, engineering, culture, expansion, and transplantation, Cell processing, storage, and banking for therapeutic application, Preclinical and QC/QA assay development, Translational and clinical scale-up and Good Manufacturing procedures and process development, Clinical protocol development, Computational and bioinformatic methods for analysis, modeling, or visualization of biological data, Negotiating the regulatory approval process and obtaining such approval for clinical trials.