qEEG Neuromarkers of Complex Childhood Trauma in Adolescents.

Abstract

Introduction. Complex childhood trauma (CCT) involves prolonged exposure to severe interpersonal stressors, leading to deficits in executive functioning and self-regulation during adolescence, a critical period for neurodevelopment. While qEEG parameters, particularly alpha oscillations, have been proposed as potential biomarkers for trauma, empirical documentation in developmental samples is limited. Aim. This preregistered study investigated whether adolescents with CCT exhibit qEEG patterns similar to those reported for PTSD, such as reduced posterior alpha power, increased individual alpha peak frequency (iAPF), right-lateralized alpha frequencies, and lower total EEG power (RMS) compared to controls. Materials and Methods. EEG data from 26 trauma-exposed adolescents and 28 controls, sourced from an open database, underwent similar preprocessing. qEEG features, including alpha power, iAPF, alpha asymmetry, and RMS, were extracted from eyes-open and eyes-closed conditions and analyzed using mixed ANOVAs. Results. Significant group differences were found in total EEG power, with trauma-exposed adolescents showing lower RMS than controls. No significant differences were found in posterior absolute alpha power, iAPF, or alpha asymmetry. However, we observed that posterior relative alpha power was higher in the trauma group, though the difference was not statistically significant but showing a small to medium effect size. Additionally, a negative correlation between CPTSD severity and EEG power in the EO condition was observed, suggesting trauma-related cortical hypoactivation. Conclusion. Reduced total EEG power and modified alpha dynamics may serve as candidate neuromarkers of CCT. These findings underscore the need for further research to validate qEEG biomarkers for understanding and diagnosing trauma-related disorders in developmental populations.