Chemical structure-biological activity of 1,4-naphthoquinone analogs as potential Aedes aegypti larvicides

IF 3.8 1区 农林科学 Q1 AGRONOMY Pest Management Science Pub Date : 2025-01-23 DOI:10.1002/ps.8656
Seong Jong Kim, Md Imdadul H. Khan, Alden S. Estep, Charles L. Cantrell, Hoang V. Le
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Abstract

1,4-Naphthoquinone compounds have shown pesticidal activity against Aedes aegypti larvae, a key vector of diseases such as dengue and Zika. However, limited knowledge of their structure–activity relationships has hindered their optimization for pesticide development. This study investigates the structure–activity relationships of 1,4-naphthoquinone, particularly 2-hydroxy-1,4-naphthoquinone and its derivatives.

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1,4-萘醌类似物作为潜在的埃及伊蚊杀幼虫剂的化学结构和生物活性
1,4-萘醌类化合物对埃及伊蚊幼虫具有杀虫活性,而埃及伊蚊是登革热和寨卡等疾病的主要传播媒介。然而,对其构效关系的了解有限,阻碍了它们在农药开发中的优化。本文研究了1,4-萘醌,特别是2-羟基1,4-萘醌及其衍生物的构效关系。
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来源期刊
Pest Management Science
Pest Management Science 农林科学-昆虫学
CiteScore
7.90
自引率
9.80%
发文量
553
审稿时长
4.8 months
期刊介绍: Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.
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