Lipid role in synapse and nuclear envelope-associated endocytic pathways in Tauopathy.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Advances in protein chemistry and structural biology Pub Date : 2025-01-01 Epub Date: 2024-08-23 DOI:10.1016/bs.apcsb.2024.08.002
Subashchandrabose Chinnathambi, Anusree Adithyan, Madhura Chandrashekar
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引用次数: 0

Abstract

Lipids play an essential role in synaptic function, significantly impacting synaptic physiology through their dynamic nature and signaling capabilities. Membrane lipids, including cholesterol, phospholipids, and gangliosides, are crucial for synaptic organization and function. They act as structural integrators and signaling molecules, guiding vesicle intracellular movement and regulating enzyme activity to support neuronal activity. The lipid compositions of pre-synaptic and post-synaptic membranes influence vesicle generation and receptor mobility, highlighting their active involvement in synaptic processes. Astrocytes also contribute to synaptic health by upholding the blood-brain barrier, regulating ion levels, and providing metabolic support. Lipid-mediated processes control synaptic plasticity and development, with astrocytes playing a crucial role in glutamate homeostasis. Amyloid-beta and Tau proteins are key in Alzheimer's disease (AD), where synaptic disruption leads to cognitive deficits. Clathrin-mediated endocytosis (CME) and caveolin-mediated endocytosis are critical pathways for lipid-mediated synaptic function, with disruptions in these pathways contributing to AD pathogenesis.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
期刊最新文献
A comprehensive high-throughput screening approach for discovering inhibitors targeting the menin-MLL1 interaction. Histone deacetylase's regulates Tau function in Alzheimer's disease. Leveraging nuclear receptor mediated transcriptional signaling for drug discovery: Historical insights and current advances. Lipid role in synapse and nuclear envelope-associated endocytic pathways in Tauopathy. Multifaceted role of HMGB1: From nuclear functions to cytoplasmic and extracellular signaling in inflammation and cancer-Review.
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