{"title":"Research Prospects for Necroptosis in Inflammatory Diseases: A Bibliometric Analysis.","authors":"Ya-Ting Tan, Mei-Juan Wang, Shu-Chao Wang","doi":"10.2174/0109298673336964250103060730","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Necroptosis is a modifiable form of cell death mainly dependent on RIPK3 and MLKL. The association between necroptosis and inflammation has been a key focus of research. An increasing number of studies have shown that necroptosis plays an important role in inflammatory diseases, such as inflammatory bowel disease.</p><p><strong>Methods: </strong>Articles published up to 2023 were searched on the Web of Science. VOSviewer, CiteSpace, Gephi, and Microsoft Office Excel were used for bibliometric analysis and visualisation. In addition, journal impact factors and journal partitions were obtained through the Web of Science.</p><p><strong>Results: </strong>A total of 3011 articles were included in this study. The number of publications and citations in the field increased year by year. China had the highest number of publications. Cell Death & Disease published the most papers in the field. P. Vandenabeele is one of the most important scholars in this field. The most cited reference was \"Molecular Mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death\".We found substantial evidence that acute kidney injury, sepsis, cancer, and other diseases are closely related to necroptosis. In addition, we found that inhibitors of necroptosis have great potential in the treatment of inflammatory diseases.</p><p><strong>Conclusion: </strong>This is the first bibliometric analysis of studies related to necroptosis in inflammatory diseases. Our results provide an overview of basic and influential research, providing a basis for the identification of valuable research directions. Furthermore, this work offers general insight into the role of necroptosis in inflammatory human diseases.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":"393-415"},"PeriodicalIF":3.5000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0109298673336964250103060730","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Necroptosis is a modifiable form of cell death mainly dependent on RIPK3 and MLKL. The association between necroptosis and inflammation has been a key focus of research. An increasing number of studies have shown that necroptosis plays an important role in inflammatory diseases, such as inflammatory bowel disease.
Methods: Articles published up to 2023 were searched on the Web of Science. VOSviewer, CiteSpace, Gephi, and Microsoft Office Excel were used for bibliometric analysis and visualisation. In addition, journal impact factors and journal partitions were obtained through the Web of Science.
Results: A total of 3011 articles were included in this study. The number of publications and citations in the field increased year by year. China had the highest number of publications. Cell Death & Disease published the most papers in the field. P. Vandenabeele is one of the most important scholars in this field. The most cited reference was "Molecular Mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death".We found substantial evidence that acute kidney injury, sepsis, cancer, and other diseases are closely related to necroptosis. In addition, we found that inhibitors of necroptosis have great potential in the treatment of inflammatory diseases.
Conclusion: This is the first bibliometric analysis of studies related to necroptosis in inflammatory diseases. Our results provide an overview of basic and influential research, providing a basis for the identification of valuable research directions. Furthermore, this work offers general insight into the role of necroptosis in inflammatory human diseases.
背景：坏死坏死是一种可改变的细胞死亡形式，主要依赖于RIPK3和MLKL。坏死性上睑下垂与炎症之间的关系一直是研究的重点。越来越多的研究表明，坏死性上睑下垂在炎症性疾病中起着重要作用，如炎症性肠病。方法：在Web of Science检索到2023年发表的文章。使用VOSviewer、CiteSpace、Gephi和Microsoft Office Excel进行文献计量学分析和可视化。此外，通过Web of Science获取期刊影响因子和期刊分区。结果：本研究共纳入3011篇文献。该领域的出版物和引用数量逐年增加。中国的出版物数量最多。《细胞死亡与疾病》在该领域发表的论文最多。P. Vandenabeele是该领域最重要的学者之一。引用最多的参考文献是“细胞死亡的分子机制：细胞死亡命名委员会的建议”。我们发现大量证据表明，急性肾损伤、败血症、癌症等疾病与坏死性上睑下垂密切相关。此外，我们发现坏死性上睑下垂抑制剂在炎症性疾病的治疗中具有很大的潜力。结论：这是第一次对炎症性疾病中坏死下垂相关研究的文献计量学分析。我们的研究结果概述了基础和有影响力的研究，为确定有价值的研究方向提供了依据。此外，这项工作为坏死性下垂在人类炎症性疾病中的作用提供了一般的见解。
期刊介绍：
Aims & Scope
Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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