Potential of Glycyrrhiza in the prevention of colitis-associated colon cancer

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2025-01-20 DOI:10.1016/j.fitote.2025.106398

Fang Liu , Zhili Gu , Feiyang Yi , Xue Liu , Wenxuan Zou , Qingxia Xu , Yun Yuan , Nianzhi Chen , Jianyuan Tang

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Abstract

Ethnopharmacological relevance

Glycyrrhiza, a legume native to the Mediterranean region, has a long history of ethnomedicinal use in China. Due to its antiviral, antibacterial, anti-inflammatory, antioxidant, antitumor, anti-ulcer, and hepatoprotective properties, Glycyrrhiza is widely utilized in the treatment of gastrointestinal disorders.

The aim of the review

The specific mechanisms of the main active constituents of glycyrrhiza in the treatment of inflammatory bowel disease, precancerous lesions and colorectal cancer at all stages of the colitis-associated colon cancer “Inflammation-Dysplasia-Cancer” sequence, as well as its pharmacokinetics, toxicology, formulation improvements, and application studies, are reviewed to provide new insights and perspectives on glycyrrhiza as a dietary supplement to treat and prevent colitis-associated colon cancer.

Materials and methods

Information on Glycyrrhiza was retrieved from electronic databases, including PubMed and Web of Science.

Results

Glycyrrhiza is a well-established medicinal plant with significant potential for applications in both the food and pharmaceutical industries. Over 400 active constituents have been identified in Glycyrrhiza, including terpenoids, flavonoids, isoflavones, coumarins, and polyphenols. Numerous studies have demonstrated that Glycyrrhiza and its active compounds can inhibit the “Inflammation-Dysplasia-Cancer” progression of colitis-associated colon cancer by mitigating inflammatory bowel disease, reducing the number of intestinal precancerous lesions, and counteracting colorectal cancer. Furthermore, derivatives and nanocarriers are crucial for the effective treatment of colitis-associated colon cancer using Glycyrrhiza and its active constituents.

Conclusion

In conclusion, Glycyrrhiza is a plant with both medicinal and nutritional value, making it a potential food ingredient and dietary supplement for the treatment of colitis-associated colon cancer.

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甘草预防结肠炎相关结肠癌的潜力。

民族药理学相关性：甘草是一种原产于地中海地区的豆科植物，在中国具有悠久的民族药用历史。由于其抗病毒、抗菌、抗炎、抗氧化、抗肿瘤、抗溃疡和保护肝脏的特性，甘草被广泛应用于胃肠道疾病的治疗。审查的目的是：综述了甘草主要活性成分在结肠炎相关结肠癌“炎症-发育不良-癌症”序列各阶段治疗炎性肠病、癌前病变和结直肠癌的具体机制，以及其药代动力学、毒理学、配方改进和应用研究，为甘草作为膳食补充剂治疗和预防结肠炎相关结肠癌提供新的见解和视角。材料和方法：从PubMed和Web of Science等电子数据库中检索甘草的相关信息。结果：甘草是一种成熟的药用植物，在食品和制药工业中都有很大的应用潜力。甘草中已鉴定出400多种有效成分，包括萜类、类黄酮、异黄酮、香豆素和多酚。大量研究表明，甘草及其活性化合物可通过减轻炎症性肠病、减少肠道癌前病变数量、对抗结直肠癌，抑制结肠炎相关结肠癌的“炎症-发育不良-癌症”进展。此外，衍生物和纳米载体对于使用甘草及其活性成分有效治疗结肠炎相关结肠癌至关重要。结论：综上所述，甘草是一种具有药用价值和营养价值的植物，是治疗结肠炎相关性结肠癌的潜在食品成分和膳食补充剂。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.