P Aiden McCormick, Marie O'Grady, Paul Holder, Cillian F De Gascun, John S Lambert, Orla Crosbie, Susan McKiernan, Maeve Skelly, Garry Courtney, Brian Hennessy, Kevin Walsh, Roisin Twohig, Kate Browne, Tessa O'Gorman, Vivion Crowley, Seán J Costelloe, Roz O'Byrne, Orla Gildea, Noreen Montgomery
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引用次数: 0
Abstract
Background: Chronic infection with hepatitis B virus and HIV causes significant morbidity and mortality. Effective antiviral treatment is available for both. Ireland has historically been considered a low prevalence country. However, with increasing inward migration and diversity, this may be changing.
Aims: The aim of this study was to measure the community prevalence of hepatitis B virus and HIV infections in Irish residents born between the years 1965 and 1985.
Methods: Anonymised residual serum samples from blood tests ordered by community general practitioners and tested in eight general hospital laboratories, spread across Ireland, were analysed for the presence of Hepatitis B surface antigen and antibodies to HIV.
Results: A total of 6080 samples were analysed for hepatitis B surface antigen including 2993 males, 2807 females and 280 samples for which gender was not recorded. HBsAg was detected in 28/6067 samples giving an estimated prevalence of 0.46% (95% CI 0.32-0.67%). Antibodies to HIV were identified in 18/6064 giving an estimated prevalence of 0.33% (95% CI 0.19-0.47%). The prevalence of both hepatitis B and HIV was significantly higher in Cork (Southwest Ireland) than other centres: hepatitis B (12/1050 vs 16/5017, p = 0.014) and HIV (11/1049 vs 7/5015, p < 0.001).
Conclusions: The prevalence of hepatitis B virus and HIV infections in this cohort appear to be higher than previously estimated. In addition, their prevalence in the Cork area appears particularly high. Whether this represents a true prevalence or a chance finding will require confirmatory studies.
背景：慢性乙型肝炎病毒和艾滋病毒感染引起显著的发病率和死亡率。对这两种疾病都有有效的抗病毒治疗。爱尔兰历来被认为是发病率较低的国家。然而，随着向内移民和多样性的增加，这种情况可能正在改变。目的：本研究的目的是测量1965年至1985年间出生的爱尔兰居民乙型肝炎病毒和艾滋病毒感染的社区患病率。方法：从遍布爱尔兰的社区全科医生和8家综合医院实验室进行的血液测试中收集匿名残留血清样本，分析乙型肝炎表面抗原和艾滋病毒抗体的存在。结果：共检测乙肝表面抗原6080份，其中男性2993份，女性2807份，未记录性别280份。在28/6067份样本中检测到HBsAg，估计患病率为0.46% （95% CI 0.32-0.67%）。在18/6064中检测到HIV抗体，估计患病率为0.33% （95% CI 0.19-0.47%）。科克（爱尔兰西南部）的乙型肝炎和艾滋病毒的患病率明显高于其他中心：乙型肝炎（12/1050 vs 16/5017, p = 0.014）和艾滋病毒（11/1049 vs 7/5015, p）结论：该队列中乙型肝炎病毒和艾滋病毒感染的患病率似乎高于先前估计。此外，它们在科克地区的患病率似乎特别高。这是否代表真正的流行或偶然发现将需要证实研究。
期刊介绍：
The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker.
The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.
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