Oncological Feasibility of Limited Neck Dissection in cN0 Supraglottic Laryngeal Cancer

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-01-23 DOI:10.1002/hed.28081

Sara Bassani, Giacomo Papi, Filippo Marani, Riccardo Nocini, Valentina Campagnari, Filippo Marchi, Marco Lionello, Chiara Varago, Alberto Paderno, Erika Crosetti, Francesco Mattioli, Edoardo Serafini, Matteo Fermi, Alessandro Rosti, Gerardo Petruzzi, Flaminia Campo, Elisa Bellini, Alberto Vito Marcuzzo, Chiara Angela Mineo, Giuseppe Mercante, Armando De Virgilio, Leone Giordano, Andrea Galli, Giuditta Mannelli, Luca Mazzetti, Gaetano Paludetti, Giorgia Rossi, Karol Zeleník, Daniel Marin Ramos, Rogèrio Aparecido Dedivitis, Giovanni Succo, Giancarlo Tirelli, Mario Bussi, Raul Pellini, Jacopo Galli, Giuseppe Spriano, Daniele Monzani, Giorgio Peretti, Andy Bertolin, Cesare Piazza, Daniele Marchioni, Livio Presutti, Gabriele Molteni

{"title":"Oncological Feasibility of Limited Neck Dissection in cN0 Supraglottic Laryngeal Cancer","authors":"Sara Bassani, Giacomo Papi, Filippo Marani, Riccardo Nocini, Valentina Campagnari, Filippo Marchi, Marco Lionello, Chiara Varago, Alberto Paderno, Erika Crosetti, Francesco Mattioli, Edoardo Serafini, Matteo Fermi, Alessandro Rosti, Gerardo Petruzzi, Flaminia Campo, Elisa Bellini, Alberto Vito Marcuzzo, Chiara Angela Mineo, Giuseppe Mercante, Armando De Virgilio, Leone Giordano, Andrea Galli, Giuditta Mannelli, Luca Mazzetti, Gaetano Paludetti, Giorgia Rossi, Karol Zeleník, Daniel Marin Ramos, Rogèrio Aparecido Dedivitis, Giovanni Succo, Giancarlo Tirelli, Mario Bussi, Raul Pellini, Jacopo Galli, Giuseppe Spriano, Daniele Monzani, Giorgio Peretti, Andy Bertolin, Cesare Piazza, Daniele Marchioni, Livio Presutti, Gabriele Molteni","doi":"10.1002/hed.28081","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Supraglottic squamous cell carcinoma (SCC) is a significant portion of head and neck cancers, with the management of clinically negative necks (cN0) through selective neck dissection (SND) being debated due to potential morbidities and low metastasis rates in levels IIb and IV.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This study is a retrospective, multicenter examination of the potential feasibility of limited neck dissection (LND), including only levels IIa and III in cN0 supraglottic SCC patients. It analyzed occult metastasis rates and explored relapse occurrences alongside potential predictors of lymph node metastasis.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among 425 patients, predominantly male (85.6%) with a mean age of 63 years, the occult metastasis rate was 28.9%, and 13.7% experienced relapses during a mean follow-up of 52 months. Advanced clinical stage, higher grading, and other risk factors emerged as predictors of occult lymph node metastasis at level IIb.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The study supports LND potential feasibility for cN0 supraglottic SCC, suggesting level IIb dissection can be omitted in specific early-stage cases to reduce morbidity without affecting outcomes.</p>\n </section>\n </div>","PeriodicalId":55072,"journal":{"name":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","volume":"47 6","pages":"1699-1705"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.28081","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Head and Neck-Journal for the Sciences and Specialties of the Head and Neck","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hed.28081","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Supraglottic squamous cell carcinoma (SCC) is a significant portion of head and neck cancers, with the management of clinically negative necks (cN0) through selective neck dissection (SND) being debated due to potential morbidities and low metastasis rates in levels IIb and IV.

Methods

This study is a retrospective, multicenter examination of the potential feasibility of limited neck dissection (LND), including only levels IIa and III in cN0 supraglottic SCC patients. It analyzed occult metastasis rates and explored relapse occurrences alongside potential predictors of lymph node metastasis.

Results

Among 425 patients, predominantly male (85.6%) with a mean age of 63 years, the occult metastasis rate was 28.9%, and 13.7% experienced relapses during a mean follow-up of 52 months. Advanced clinical stage, higher grading, and other risk factors emerged as predictors of occult lymph node metastasis at level IIb.

Conclusions

The study supports LND potential feasibility for cN0 supraglottic SCC, suggesting level IIb dissection can be omitted in specific early-stage cases to reduce morbidity without affecting outcomes.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

有限颈部清扫治疗cN0声门上喉癌的肿瘤学可行性。

背景：声门上鳞状细胞癌（SCC）是头颈部癌症的重要组成部分，由于IIb和iv水平的潜在发病率和低转移率，通过选择性颈部清扫（SND）来治疗临床阴性颈部（cN0）一直存在争议。方法：本研究是一项回顾性的多中心研究，研究有限颈部清扫（LND）的潜在可行性，仅包括cN0水平的声门上鳞状细胞癌（SCC）的IIa和III。它分析了隐性转移率，并探讨了复发发生率以及淋巴结转移的潜在预测因素。结果：425例患者中，男性占85.6%，平均年龄63岁，隐匿转移率28.9%，平均随访52个月复发13.7%。临床分期较晚、分级较高和其他危险因素成为IIb级隐匿淋巴结转移的预测因素。结论：该研究支持LND治疗cN0声门上鳞状细胞癌的潜在可行性，提示在特定的早期病例中可以省略IIb层剥离，以降低发病率而不影响预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.