Drusen Regression Following Macular Hole Surgery: A Case Report.

Q3 Medicine Retinal Cases and Brief Reports Pub Date : 2025-01-17 DOI:10.1097/ICB.0000000000001720

Shannan Berzack, Prashant K Parekh

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Abstract

Purpose: To report a case of drusen regression following pars plana vitrectomy with internal limiting membrane peel (ILMP) in a patient with a full-thickness macular hole and dry age-related macular degeneration (AMD).

Methods: A 67-year-old gentleman presented in April 2024 with a full-thickness macular hole in OS and intermediate dry AMD OU. The patient underwent pars plana vitrectomy, ILMP, and an injection of sulfur hexafluoride gas for macular hole repair in OS. The patient's macular changes were monitored through visual acuity, fundus examination and optical coherence tomography (OCT) imaging at baseline and follow-up visits.

Results: The macular hole was closed and there was early stability of the macular drusen in OU. At a five-month follow-up in September 2024, he reported improved vision from 20/100 baseline to 20/40. Fundus examination as well as OCT imaging demonstrated a significant reduction of macular drusen in the operated eye, which was not observed in the fellow eye.

Conclusion: This case demonstrates successful surgical management of a full-thickness macular hole in a patient with concomitant drusen regression. The regression of drusen was limited to the operated eye, which suggests that surgical interventions may influence the course of AMD in certain patients.

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