Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Kegang Cao
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Abstract
Background: Migraine represents a chronic neurological disorder characterized by high prevalence, substantial disability rates, and significant economic burden. Its pathogenesis is complex, and there is currently no cure. The rapid progress in multi-omics technologies has provided new tools to uncover the intricate pathological mechanisms underlying migraine. This systematic review aims to synthesize the findings of multi-omics studies on migraine to further elucidate the complex mechanisms of disease onset, thereby laying a scientific foundation for identifying new therapeutic targets.
Methods: We conducted a comprehensive systematic review, specifically focusing on clinical observational studies that investigate various aspects of migraine through the integration of genomics, transcriptomics, proteomics, and metabolomics. Our search encompassed multiple databases including PubMed, EMBASE, the Web of Science Core Collection, the Cochrane Library, China National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database, the Wanfang database, and the China Biology Medicine Database to cover studies from database inception until 20 March 2024., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).
Results: A total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.
Conclusion: Multi-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.
背景：偏头痛是一种慢性神经系统疾病，其特点是患病率高，致残率高，经济负担重。其发病机制复杂，目前尚无治愈方法。多组学技术的快速发展为揭示偏头痛复杂的病理机制提供了新的工具。本文旨在综合近年来偏头痛多组学研究成果，进一步阐明偏头痛发病的复杂机制，为寻找新的治疗靶点奠定科学基础。方法：我们进行了一项全面的系统综述，特别关注临床观察研究，通过基因组学、转录组学、蛋白质组学和代谢组学的整合研究偏头痛的各个方面。我们检索了多个数据库，包括PubMed、EMBASE、Web of Science核心合集、Cochrane图书馆、中国国家知识基础设施、中国科技期刊数据库、万方数据库和中国生物医学数据库，涵盖了从数据库建立到2024年3月20日的研究。我们综述的范围包括偏头痛的各个方面，如发作期和发作间期；发作性或慢性偏头痛；menstrual-related偏头痛;伴有或不伴有先兆的偏头痛（PROSPERO注册号：CRD42024470268）。结果：总共纳入了38项研究，突出了一系列与偏头痛相关的遗传变异、转录异常、蛋白质功能改变和代谢途径中断。这些多组学研究结果强调了线粒体功能障碍、炎症反应和氧化应激在偏头痛病理生理中的关键作用。结论：多组学方法为理解偏头痛复杂的病理生理提供了新的视角和工具，有助于发现潜在的生物标志物和治疗靶点。系统综述注册：https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=470268，标识符CRD42024470268。
期刊介绍：
Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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