Successful treatment of severe acrodermatitis continua of hallopeau with Bimekizumab: A case report.

Abstract

Acrodermatitis continua of Hallopeau is a rare form of pustular psoriasis affecting the acral fingers and toes, characterized by recurrent eruptions of sterile pustules that lead to significant pain and potentially irreversible destruction of the nail apparatus. Symptoms are often refractory to topical and systemic therapies for psoriasis. This case report presents a healthy 23-year-old female with severe acrodermatitis continua of Hallopeau, destructing all 10 fingernails. Treatment with Bimekizumab, a monoclonal antibody that inhibits interleukin-17, led to 50% improvement by 2 months, and complete normal regrowth of all fingernails by 1 year. The medication was tolerated well without any reported side effects. This is the second reported case of successful acrodermatitis continua of Hallopeau treatment with Bimekizumab, highlighting its potential as an effective and safe option for this challenging and recalcitrant condition.