Acute therapeutic effects and pathophysiology of eosinophilic granulomatosis with polyangiitis neuropathy.

IF 2.1 Q3 CLINICAL NEUROLOGY BMJ Neurology Open Pub Date : 2025-01-19 eCollection Date: 2025-01-01 DOI:10.1136/bmjno-2024-000938
Nanami Yamanaka, Yukio Takeshita, Ryota Sato, Takashi Nawata, Tatsuya Okafuji, Susumu Fujikawa, Miwako Fujisawa, Kinya Matsuo, Joe Nemoto, Yuki Mizumoto, Hideaki Nishihara, Masaya Honda, Mariko Oishi, Toshihiko Maeda, Fumitaka Shimizu, Michiaki Koga, Takashi Kanda, Masayuki Nakamori
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引用次数: 0

Abstract

Objective: This study investigated the effects of early treatment and pathophysiology on eosinophilic granulomatosis with polyangiitis neuropathy (EGPA-N).

Methods: Twenty-six consecutive patients with EGPA-N were diagnosed and treated within a day of admission and underwent clinical analysis. Peripheral nerve recovery rates were evaluated after early treatment by identifying the damaged peripheral nerve through detailed neurological findings.

Results: The eosinophil count at onset was significantly correlated with the total number of damaged nerves. There was a strong correlation between the timing of treatment and the recovery rate in patients who started treatment within 50 days, as the recovery rate did not increase after 50 days of treatment. Antineutrophil cytoplasmic antibodies (ANCA)-negative cases showed significantly higher recovery rates than ANCA-positive cases. Vasculitis was detected in 67% of ANCA-positive and 29% of ANCA-negative patients in the sural nerve and skin biopsy specimen. In addition, infiltration of eosinophils into peripheral nerve tissues was observed in 40% of ANCA-negative patients, whereas it was absent in ANCA-positive patients. Intrafascicular oedema was found in 95% of all patients.

Discussion: Our results suggest three pathological pathways: (1) ischaemic peripheral nerve due to vasculitis mainly in ANCA-positive cases, (2) direct infiltration and degranulation of eosinophils in ANCA-negative cases and (3) progression of axonal ischaemia due to intrafascicular oedema in both cases. The study also found that ANCA-negative cases exhibited better responsiveness to acute-phase treatment than ANCA-positive cases. It is essential to treat patients with EGPA-N as early as possible because the patients could recover time-dependently within 50 days of the onset.

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来源期刊
BMJ Neurology Open
BMJ Neurology Open Medicine-Neurology (clinical)
CiteScore
3.20
自引率
3.70%
发文量
46
审稿时长
13 weeks
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