Digital Image Analysis of Vertebral Body S1 and Its Ossification Center in the Human Fetus.

IF 2.8 3区医学 Q3 NEUROSCIENCES Brain Sciences Pub Date : 2025-01-15 DOI:10.3390/brainsci15010074

Magdalena Grzonkowska, Katarzyna Bogacz, Andrzej Żytkowski, Monika Szkultecka-Dębek, Michał Kułakowski, Michał Janiak, Agnieszka Rogalska, Mariusz Baumgart

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Abstract

Objectives: The aim of the present study was to examine the growth dynamics of the first sacral vertebra and its ossification center in the human fetus, based on their linear, planar, and volumetric parameters.

Methods: The examinations were carried out on 54 human fetuses of both sexes (26 males and 28 females) aged 18-30 weeks of gestation, which had been preserved in 10% neutral formalin solution. Using CT, digital image analysis software, 3D reconstruction, and statistical methods, the size of the first sacral vertebra and its ossification center was evaluated.

Results: The first sacral vertebra and its ossification center grew proportionately according to fetal weeks.

Conclusions: The numerical data obtained from computed tomography and the growth patterns of the body of the first sacral vertebra and its ossification center may serve as age-specific normative intervals relevant for gynecologists, obstetricians, pediatricians, and radiologists during fetal ultrasound screening. Our findings on the growth of the body of the first sacral vertebra and its ossification center may be useful in daily clinical practice, particularly in ultrasonic monitoring of normal fetal growth and in screening for congenital defects and skeletal dysplasias.

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人胎儿S1椎体及其骨化中心的数字图像分析。

目的：本研究的目的是研究人类胎儿第一骶椎及其骨化中心的生长动力学，基于它们的线性、平面和体积参数。方法：采用10%中性福尔马林溶液保存的18 ~ 30孕周男女胎儿54例（男26例，女28例）。采用CT、数字图像分析软件、三维重建及统计学方法对第一骶椎及其骨化中心大小进行评估。结果：第一骶椎及其骨化中心按胎周比例生长。结论：计算机断层扫描获得的数值数据和第一骶椎体及其骨化中心的生长模式可以作为胎儿超声筛查时妇科、产科、儿科和放射科医生的年龄特异性规范间隔。我们关于第一骶椎体及其骨化中心生长的研究结果可能在日常临床实践中有用，特别是在超声监测正常胎儿生长和筛查先天性缺陷和骨骼发育不良方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Sciences Neuroscience-General Neuroscience

CiteScore

4.80

自引率

9.10%

发文量

1472

审稿时长

18.71 days

期刊介绍： Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.