The impact of Mycoplasma pneumoniae infection on platelets in children with immune thrombocytopenia: a real-world study from China

IF 2.4 3区医学 Q2 HEMATOLOGY Annals of Hematology Pub Date : 2025-01-25 DOI:10.1007/s00277-024-06179-9

Nan Wang, Zhifa Wang, Juntao Ouyang, Jingyao Ma, Yunyun Wei, Yu Hu, Jingjing Liu, Shuyue Dong, Jinxi Meng, Xiaoling Cheng, Runhui Wu

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Abstract

Mycoplasma pneumoniae (M. pneumoniae), as one of the susceptible pathogens during childhood, may lead to severe mycoplasmal pneumonia and affect platelet fluctuations. We prospectively collected data on persistent/chronic ITP children who were infected with M. pneumoniae infection from August 2023 to December 2023. There were 64 patients (40 males) with a median age of 7.08 years (range 4.30 to 9.76) enrolled in this study. Overall, 33 (51.6%) children received TPO-RAs therapy and 31 (48.4%) received other treatments. The impact of M. pneumoniae infection on platelet count is bidirectional, but thrombocytopenia remains predominant. During M. pneumoniae infection, platelet changes in the TPO-RA group were higher than in the non-TPO-RA group. Thrombocytosis was observed in 6 patients (5 in the TPO-RA group vs. 1 in the non-TPO-RA group). Rescue treatment was implemented in 18 patients (7 in the TPO-RA group vs. 11 in the non-TPO-RA group). Monitoring platelets should be strengthened during M. pneumoniae infection.

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肺炎支原体感染对免疫性血小板减少症儿童血小板的影响：一项来自中国的真实世界研究

肺炎支原体（Mycoplasma pneumoniae， M. pneumoniae）是儿童时期的易感病原体之一，可导致严重的支原体肺炎，影响血小板波动。我们前瞻性地收集了2023年8月至2023年12月感染肺炎支原体感染的持续性/慢性ITP儿童的数据。本研究共纳入64例患者，其中男性40例，中位年龄7.08岁（范围4.30 ~ 9.76）。总体而言，33名（51.6%）儿童接受了TPO-RAs治疗，31名（48.4%）接受了其他治疗。肺炎支原体感染对血小板计数的影响是双向的，但血小板减少仍然是主要的。肺炎支原体感染期间，TPO-RA组血小板变化高于非TPO-RA组。6例患者出现血小板增多（TPO-RA组5例，非TPO-RA组1例）。18例患者接受了抢救治疗（TPO-RA组7例，非TPO-RA组11例）。肺炎支原体感染期间应加强血小板监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Hematology 医学-血液学

CiteScore

5.60

自引率

2.90%

发文量

304

审稿时长

2 months

期刊介绍： Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology.