Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomolecules Pub Date : 2025-01-03 DOI:10.3390/biom15010056

Zhiruo Qiu, Jiahui Guo, Bofei Chen, Jiajia Fang

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Abstract

Epilepsy is a prevalent chronic neurological disorder that can significantly impact patients' lives. The incidence and risk of psychosis in individuals with epilepsy are notably higher than in the general population, adversely affecting both the management and rehabilitation of epilepsy and further diminishing patients' quality of life. This review provides an overview of the classification and clinical features of psychosis of epilepsy, with the aim of offering insights and references for the clinical diagnosis and treatment of various types of psychosis of epilepsy. Additionally, we examine the potential pathophysiological mechanisms underlying the psychosis of epilepsy from three perspectives: neuroimaging, neurobiology, and genetics. The alterations in brain structure and function, neurotransmitters, neuroinflammatory mediators, and genetic factors discussed in this review may offer insights into the onset and progression of psychotic symptoms in epilepsy patients and are anticipated to inform the identification of novel therapeutic targets in the future.

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癫痫精神病：临床分类和发病机制的最新进展。

癫痫是一种常见的慢性神经系统疾病，可严重影响患者的生活。癫痫患者精神病的发病率和风险明显高于一般人群，对癫痫的管理和康复产生不利影响，并进一步降低患者的生活质量。本文就癫痫精神病的分类及临床特点进行综述，以期为各类癫痫精神病的临床诊断和治疗提供参考。此外，我们从神经影像学、神经生物学和遗传学三个角度探讨癫痫精神病的潜在病理生理机制。本综述中讨论的脑结构和功能、神经递质、神经炎症介质和遗传因素的改变可能为癫痫患者精神病性症状的发生和进展提供见解，并有望为未来确定新的治疗靶点提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.