Diagnostic Accuracy of Shear Wave Elastography in Predicting Malignant Origins of Pleural Effusions in Emergency Departments.

Abstract

Objective: Ultrasound is a valuable diagnostic tool in the diagnostic work-up of dyspnea and can identify even small pleural effusions. The incorporation of shear wave elastography (SWE) represents a possible tool in stratifying pleural effusions by the risk of underlying malignancy. No previous studies on ultrasound with the incorporation of SWE have been conducted in an emergency department (ED), where such stratification might have a clinical impact by hastening referrals for the diagnostic work-up of underlying malignancy. The objective of this study was to appraise the diagnostic accuracy of ultrasonographic findings associated with thoracic malignancy as well as to calculate the optimal cutoff values for SWE in this regard. Methods: Patients with a unilateral pleural effusion of unknown origin were included in the ED and subjected to a thoracic ultrasound (TUS) scan during their first 48 h after admittance. Two index tests were applied: (i) traditional B-mode TUS examination registering the presence of diaphragmatic nodules, pleural thickenings and other findings associated with malignancy and (ii) an SWE examination of different regions of interest. The reference test was defined as the subsequent diagnosis of malignant pleural effusion (MPE) in the three months following inclusion. Results: In total, 39 patients were included. The B-mode TUS index test yielded a sensitivity of 28.57% (95%CI 3.67-70.96%) and a specificity of 90.62% (95%CI 74.98-98.02%). The SWE max of the intercostal space yielded a sensitivity of 100% (95%CI 47.82-100%) and a specificity of 59.09% (95%CI 36.35-79.29%). Conclusions: A TUS with integrated SWE may aid in identifying MPEs and improving referrals for the diagnostic work-up of underlying malignancy. Larger, adequately powered studies are warranted.